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首页> 外文期刊>Life sciences >Effect of melatonin on bone metabolism in ovariectomized rats.
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Effect of melatonin on bone metabolism in ovariectomized rats.

机译：褪黑激素对去卵巢大鼠骨骼代谢的影响。

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摘要

To assess the effect of pharmacological dose of melatonin on bone metabolism in ovariectomized rats, urinary deoxypyridinoline (a marker of bone resorption) and calcium excretion, circulating levels of calcium, phosphorus and bone alkaline phosphatase activity (a marker of bone formation), and bone mineral density (BMD), mineral content (BMC) and bone area (BA) of total body, were measured in adult rats for up to 60 days after surgery. Rats received melatonin in the drinking water (25 microg/ml water) or drinking water alone. Urinary deoxypyridinoline increased significantly after ovariectomy by 51% (30 days after surgery) and by 47% (60 days after surgery). The increase in urinary deoxypyridinoline found 30 days after ovariectomy was not observed in melatonin-treated rats. Urinary calcium concentration was similar in the 4 experimental groups studied, as was the circulating calcium concentration at every time interval examined. Fifteen days after surgery, a significant increase in serum phosphorus and bone alkaline phosphatase levels occurred in ovariectomized rats receiving melatonin as compared to their controls. Sixty days after surgery BMD, BMC and BA decreased significantly in ovariectomized rats, an effect not modified by melatonin. Serum estradiol decreased significantly by 30 days after ovariectomy to attain values close to the limit of detection of the assay by 60 days after ovariectomy. The results support the conclusion that a pharmacological amount of melatonin modifies bone remodeling after ovariectomy and that the effect may need adequate concentrations of estradiol.
机译：评估褪黑激素的药理剂量对去卵巢大鼠骨代谢，尿中的脱氧吡啶并啉（骨吸收的标志）和钙排泄，钙，磷和骨碱性磷酸酶活性的循环水平（骨形成的标志）以及骨的影响在手术后长达60天的成年大鼠中测量了全身的矿物质密度（BMD），矿物质含量（BMC）和骨骼面积（BA）。大鼠在饮用水（25微克/毫升水）或仅饮用水中接受褪黑激素。卵巢切除术后尿中的脱氧吡啶并啉显着增加51％（手术后30天）和47％（手术后60天）。卵巢切除术后30天发现的褪黑素处理的大鼠尿中脱氧吡啶啉的增加。在所研究的4个实验组中，尿钙浓度相似，每个检查时间间隔的循环钙浓度也相同。手术后十五天，接受褪黑激素的卵巢切除大鼠与对照组相比，血清磷和骨碱性磷酸酶水平显着增加。手术后六十天，去卵巢大鼠的BMD，BMC和BA明显降低，褪黑激素并未改变这种作用。卵巢切除术后30天血清雌二醇显着降低，达到卵巢切除术后60天接近检测限的水平。该结果支持这样的结论：褪黑激素的药理作用可改变卵巢切除术后的骨重塑，并且该作用可能需要适当浓度的雌二醇。

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