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首页> 外文期刊>Life sciences >The release of bradykinin in bovine mastitis.
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The release of bradykinin in bovine mastitis.

机译：缓激肽在牛乳腺炎中的释放。

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The kinin peptides are released during inflammation and are amongst the most potent known mediators of vasodilatation, pain and oedema. Despite early reports of the presence of kinins in milk, no previous study has investigated the role of the kinin system in bovine mastitis. The present study indicated that mastitis was accompanied by raised levels of bradykinin (BK) in milk and the increased levels of BK correlated with the severity of mastitis. Raised BK levels in mastitic milk were not dependent on the presence of inflammatory cells, nor were they secondary to changes in blood levels of BK. In milk from sub-clinically inflamed quarters, BK was raised in those milks where Staphylococcus aureus (S. aureus) was isolated but not in those milks where no pathogen was isolated. Increasing S. aureus artificially, also caused an increase in the milk BK. Increases in milk BK were not restricted only to the mastitic quarters of the udder. In udders in which mastitis was detected in one or more quarters, BK increases were also detected in the apparently uninvolved quarters.
机译：激肽在炎症过程中被释放，并且是血管扩张，疼痛和水肿最有效的已知介体之一。尽管早期有关于牛奶中激肽存在的报道，但以前没有研究调查激肽系统在牛乳腺炎中的作用。本研究表明，乳腺炎伴随着牛奶中缓激肽（BK）水平的升高，而BK水平的升高与乳腺炎的严重程度相关。乳香中BK的水平升高不依赖于炎症细胞的存在，也不依赖于BK血液水平的变化。在亚临床发炎季度的牛奶中，分离出金黄色葡萄球菌（金黄色葡萄球菌）的那些牛奶中的BK升高，而没有分离出病原体的那些牛奶中的BK升高。人为增加金黄色葡萄球菌也导致牛奶中BK的增加。牛奶中BK的增加不仅限于乳房的乳突处。在一个或多个季度中检测到乳腺炎的乳房中，在明显不相关的季度中也检测到BK升高。

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