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首页> 外文期刊>Life sciences >Involvement of 1,2-diacylglycerol in improvement of heart function by etomoxir in diabetic rats.
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Involvement of 1,2-diacylglycerol in improvement of heart function by etomoxir in diabetic rats.

机译：1,2-二酰基甘油参与糖尿病大鼠依托莫司改善心功能的作用。

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Abnormal lipid metabolism has been proposed to be involved in the pathogenesis of diabetic cardiomyopathy. In this study, we measured myocardial lipid levels, including 1,2-diacylglycerol (1,2-DAG) and ceramide (CM), and myocardial function in diabetic rats. We also evaluated the effects of etomoxir (ETM), a carnitine palmitoyl transferase I inhibitor, on diabetic rat hearts from the viewpoints of alterations in lipid second messengers and myocardial function. Rats were injected with streptozotocin (60 mg/kg) to induce diabetes and were treated 5 weeks later with ETM (18 mg/kg) for 8 days. In diabetic rats, heart rate, systolic blood pressure, and fractional shortening were significantly reduced compared with those in controls. Treatment of diabetic rats with ETM ameliorated myocardial dysfunction other than heart rate. Myocardial 1,2-DAG levels in diabetic rats were significantly elevated compared with those in controls, while myocardial CM levels were not. ETM treatment caused an additional increase in myocardial 1,2-DAG levels in diabetic rats, but the CM levels did not change. There was a marked difference in fatty acid pattern of 1,2-DAG between diabetic and ETM-treated diabetic rat hearts. The fatty acids 18:1 and 18:2 were significantly increased and the fatty acids 16:0, 18:0, 20:4, and 22:6 were significantly reduced in ETM-treated diabetic rat hearts. These data suggest 1,2-DAG is involved in ameliorating myocardial dysfunction in diabetic rats and that its source is different between diabetic and ETM-treated diabetic rats. CM is unlikely to be involved in the pathogenesis of diabetic cardiomyopathy or the improvement of cardiac contractility in diabetic rats by ETM.
机译：已经提出脂质代谢异常与糖尿病性心肌病的发病机理有关。在这项研究中，我们测量了糖尿病大鼠的心肌脂质水平，包括1,2-二酰甘油（1,2-DAG）和神经酰胺（CM），以及心肌功能。从脂质第二信使和心肌功能的改变的角度，我们还评估了依托莫司（ETM）（一种肉碱棕榈酰转移酶I抑制剂）对糖尿病大鼠心脏的影响。给大鼠注射链脲佐菌素（60 mg / kg）以诱导糖尿病，并在5周后用ETM（18 mg / kg）治疗8天。与对照组相比，糖尿病大鼠的心率，收缩压和缩短分数明显降低。用ETM治疗糖尿病大鼠可改善除心率以外的​​心肌功能障碍。与对照组相比，糖尿病大鼠的心肌1,2-DAG水平明显升高，而心肌CM水平则没有升高。 ETM治疗使糖尿病大鼠的心肌1,2-DAG水平进一步增加，但CM水平没有变化。糖尿病和经ETM治疗的糖尿病大鼠心脏之间的1,2-DAG脂肪酸模式存在显着差异。在用ETM治疗的糖尿病大鼠心脏中，脂肪酸18：1和18：2显着增加，脂肪酸16：0、18：0、20：4和22：6显着减少。这些数据表明1,2-DAG参与改善糖尿病大鼠的心肌功能障碍，并且其来源在糖尿病大鼠和经ETM治疗的糖尿病大鼠之间是不同的。通过ETM，CM不太可能参与糖尿病性心肌病的发病机理或改善糖尿病大鼠的心脏收缩力。

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