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首页> 外文期刊>Life sciences >ACUTE AND CHRONIC EFFECTS OF MARIJUANA SMOKING ON PULMONARY ALVEOLAR PERMEABILITY
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ACUTE AND CHRONIC EFFECTS OF MARIJUANA SMOKING ON PULMONARY ALVEOLAR PERMEABILITY

机译：大麻吸烟对肺小泡通透性的急性和慢性影响

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Pulmonary clearance of technetium (Tc-99m)-labeled diethylene triamine pentaacetate (DTPA), a sensitive test of alveolar epithlelial permeability, was measured twice in 34 healthy subjects, including 10 control nonsmokers (NS), 10 habitual smokers of marijuana alone (MS) (greater than or equal to 10 joints/wk), 9 regular smokers of tobacco alone (TS) (greater than or equal to 15 cigarettes/day) and 4 habitual smokers of both marijuana and tobacco (MTS). In smokers, the first study was performed after greater than or equal to 12 hrs of abstinence from smoking to assess chronic effects of marijuana and/or tobacco smoking on alveolar permeability; the second study was performed within 15 min of smoking to assess possible acute effects. TS exhibited abnormally rapid Tc-99m-DTPA clearance after greater than or equal to 12 hours of abstinence, indicating an increase in pulmonary epithelial permeability, consistent with chronic tobacco-induced lung injury. MS showed a more modest and less consistent chronic effect than TS on Tc-99m-DTPA clearance, suggesting a more variable and smaller degree of marijuana-induced lung injury. No acute effect of tobacco or marijuana smoking on Tc-99m-DTPA clearance was apparent. Concomitant habitual smoking of marijuana and tobacco had no additive effect on alveolar permeability. [References: 21]
机译：34（Tc-99m）标记的二乙酸三亚乙基三胺五乙酸酯（DTPA）的肺清除率在34例健康受试者中进行了两次测量，其中包括10名对照非吸烟者（NS），10名习惯性吸食大麻的吸烟者（MS ）（每星期大于或等于10个关节），9个定期抽烟的单独吸烟者（TS）（大于或等于15支香烟/天）和4个习惯性抽烟的大麻和烟草（MTS）。在吸烟者中，第一次戒烟是在戒烟大于或等于12小时后进行的，以评估大麻和/或抽烟对肺泡通透性的慢性影响;第二项研究在吸烟后15分钟内进行，以评估可能的急性影响。在戒断大于或等于12小时后，TS表现出异常快速的Tc-99m-DTPA清除，表明肺上皮通透性增加，与慢性烟草诱发的肺损伤一致。 MS对Tc-99m-DTPA清除显示出比TS更温和，更不持久的慢性影响，表明大麻引起的肺损伤变化更大，程度更小。吸烟或吸食大麻对Tc-99m-DTPA清除没有急性影响。大麻和烟草的惯常吸烟对肺泡通透性没有累加作用。 [参考：21]

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