VIP-ellipticine derivatives inhibit the growth of breast cancer cells.

Moody TW; Czerwinski G; Tarasova NI; Michejda CJ

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VIP-ellipticine derivatives inhibit the growth of breast cancer cells.

机译：VIP-玫瑰树碱衍生物抑制乳腺癌细胞的生长。

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The effects of vasoactive intestinal peptide (VIP)-ellipticine (E) derivatives were investigated on breast cancer cells. VIP-ALALA-E and VIP-LALA-E inhibited 125I-VIP binding to MCF-7 cells with an IC(50) values of 1 and 0.2 microM respectively. VIP-ALALA-E and VIP-LALA-E caused elevation of cAMP in MCF-7 cells with ED(50) values of 1 and 0.1 microM. VIP-LALA-E caused increased c-fos mRNA in MCF-7 cells. Radiolabeled VIP-LALA-E was internalized at 37 degrees C and delivered the cytotoxic E into MCF-7 cells. VIP-LALA-E inhibited the clonal growth of MCF-7 cells, decreased cell viability based on trypan blue exclusion and reduced 35S-methionine uptake. These results indicate that VIP-E derivatives function as breast cancer VPAC(1) receptor agonists which inhibit MCF-7 cellular viability.

机译：研究了血管活性肠肽（VIP）-玫瑰树碱（E）衍生物对乳腺癌细胞的作用。 VIP-ALALA-E和VIP-LALA-E抑制125I-VIP与MCF-7细胞的结合，IC（50）值分别为1和0.2 microM。 VIP-ALALA-E和VIP-LALA-E导致MCF-7细胞中cAMP升高，ED（50）值为1和0.1 microM。 VIP-LALA-E导致MCF-7细胞中c-fos mRNA增加。放射性标记的VIP-LALA-E在37摄氏度下被内化，并将细胞毒性E传递到MCF-7细胞中。 VIP-LALA-E抑制MCF-7细胞的克隆生长，基于锥虫蓝排除作用降低了细胞活力，并降低了35S-蛋氨酸的摄取。这些结果表明VIP-E衍生物起抑制MCF-7细胞生存力的乳腺癌VPAC（1）受体激动剂的作用。

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《Life sciences》 |2002年第9期|共10页
作者
Moody TW; Czerwinski G; Tarasova NI; Michejda CJ;
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正文语种 eng
中图分类生命的起源;生命科学总论;
关键词
Breast Neoplasms; Cell Division; Ellipticines; Vasoactive Intestinal Peptide; 乳腺肿瘤; 细胞分裂; 玖瑰树碱类; 血管活性肠肽;

机译：Breast Neoplasms;Cell Division;Ellipticines;Vasoactive Intestinal Peptide;乳腺肿瘤;细胞分裂;玖瑰树碱类;血管活性肠肽;

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1. VIP-ellipticine derivatives inhibit the growth of breast cancer cells. [J] . Moody TW, Czerwinski G, Tarasova NI, Life sciences . 2002,第9期

机译：VIP-玫瑰树碱衍生物抑制乳腺癌细胞的生长。
2. Strigolactones: a novel class of phytohormones that inhibit the growth and survival of breast cancer cells and breast cancer stem-like enriched mammosphere cells. [J] . C B Pollock, H Koltai, Y Kapulnik, Breast cancer research and treatment. . 2012,第3期

机译：Strigolactones：一种新的植物激素，可抑制乳腺癌细胞和富含乳腺癌干样的乳腺球细胞的生长和存活。
3. SU11248, a selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells. [J] . Young E, Miele L, Tucker KB, Cancer biology & therapy . 2010,第7期

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4. Ability of Dibutyltin Polyamine Derivatives of Diaminopyrimidines to Inhibit Ovarian, Bone, Colon, Lung, and Breast Cancer Cells [C] . Kimberly Shahi, Michael R. Roner, Amitabh Battin PMSE Symposia . 2007

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5. Preferential estrogen receptor beta ligands inhibit proliferation and reduce Bcl-2 expression in Fulvestrant-resistant breast cancer cells. [D] . Ruddy, Samantha C. 2013

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6. A Radicicol Derivative KF58333 Inhibits Expression of Hypoxia‐inducible Factor‐1α and Vascular Endothelial Growth Factor Angiogenesis and Growth of Human Breast Cancer Xenografts [O] . Junichi Kurebayashi, Takemi Otsuki, Masafumi Kurosumi, 2001

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机译：新的2α，5α，10β，14β-四乙酰氧基-4（20），11-紫杉二烯（sIa）衍生物通过抑制mapK信号传导和增加乳腺癌细胞中紫杉醇的积累来克服紫杉醇抗性。

VIP-ellipticine derivatives inhibit the growth of breast cancer cells.

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