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首页> 外文期刊>Cell biology international. >Assessment of the antitumour activity of targeted immunospecific albumin microspheres loaded with cisplatin and 5-fluorouracil: toxicity against a rodent ovarian carcinoma in vitro.
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Assessment of the antitumour activity of targeted immunospecific albumin microspheres loaded with cisplatin and 5-fluorouracil: toxicity against a rodent ovarian carcinoma in vitro.

机译：负载顺铂和5-氟尿嘧啶的靶向免疫特异性白蛋白微球的抗肿瘤活性评估：对啮齿类卵巢癌的体外毒性。

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摘要

The 3-(4,5 dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) assay is used successfully to estimate the number of viable cells in drug screening trials. We used the MTT assay to assess the viability of a rodent ovarian carcinoma cell line (DMBA-OC-1R) after exposure to combinations of cisplatin and 5-fluorouracil as free drug and in encapsulated (conjugated and unconjugated) forms. After 48 h of exposure to free drugs, a significant trend towards cell cytotoxicity could be observed and this was well established by 120 h. Cells treated with drug-containing immuno-microspheres showed a similar initial decrease in cell viability after 96 h, and this was maintained for 128 h. These results suggest that immuno-microspheres loaded with chemotherapeutic drugs have the potential to be successfully used in the treatment of ovarian cancer. Copyright 2001 Academic Press.
机译：3-（4,5二甲基噻唑-2-基）-2,5二苯基四唑溴化物（MTT）测定法已成功用于估计药物筛选试验中的活细胞数量。在暴露于顺铂和5-氟尿嘧啶的组合作为游离药物并以包封（结合和未结合）形式暴露后，我们使用MTT分析评估了啮齿动物卵巢癌细胞系（DMBA-OC-1R）的活力。暴露于游离药物48小时后，可以观察到细胞毒性的显着趋势，并且在120 h时已经很好地确定了。用含药物的免疫微球处理的细胞在96小时后显示出类似的细胞活力初始下降，并维持128小时。这些结果表明，载有化学治疗药物的免疫微球具有成功用于卵巢癌治疗的潜力。版权所有2001，学术出版社。

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