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首页> 外文期刊>Cellular immunology >gamma Chain transducing element: a shared pathway between endocrine and immune system.
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gamma Chain transducing element: a shared pathway between endocrine and immune system.

机译：γ链转导元件：内分泌和免疫系统之间的共享途径。

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摘要

Several molecules, involved in the intracellular communication network, have been identified as the cause of primary immunodeficiencies. In most cases, these molecules are exclusively expressed in hematopoietic cells, being involved in cell development and/or functionality of terminal differentiated cells of immune system. In the case of gammac, the abundance of the protein suggests a potential pleiotropic effect of the molecule. Immune and endocrine systems participate to an integrated network of soluble mediators that communicate and coordinate responsive cells to achieve effector functions in an appropriate fashion. It has been demonstrated a novel dependence of GH signaling on the common cytokines receptor gammac in certain cell types, supporting the hypothesis of an interplay between endocrine and immune system. The evidence that different receptors share a few molecules may certainly lead to a better knowledge on the mechanism of coordination and integration of several pathways implicated in the control of cell growth and proliferation under physiological or pathogenic conditions. This review focuses on the gammac as a common transducing element shared between several cytokines and growth hormone receptors, indicating a further functional link between endocrine and immune system.
机译：已经确定了参与细胞内通讯网络的几种分子是原发性免疫缺陷的原因。在大多数情况下，这些分子仅在造血细胞中表达，参与细胞的发育和/或免疫系统终末分化细胞的功能。就gammac而言，该蛋白质的丰度表明该分子具有潜在的多效作用。免疫系统和内分泌系统参与了可溶性介体的集成网络，该介体通过适当的方式交流和协调反应性细胞以实现效应子功能。已经证明GH信号传导对某些细胞类型中的常见细胞因子受体gammac具有新的依赖性，支持内分泌和免疫系统之间相互作用的假设。不同受体共享少数分子的证据肯定会导致人们更好地了解在生理或致病条件下与细胞生长和增殖控制有关的几种途径的协调和整合机制。这项审查集中在gammac作为几种细胞因子和生长激素受体之间共享的常见的转导元件，表明内分泌和免疫系统之间的进一步功能联系。

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