...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Genetic similarities between organogenesis and tumorigenesis of the lung.
【24h】

Genetic similarities between organogenesis and tumorigenesis of the lung.

机译：肺器官发生与肿瘤发生之间的遗传相似性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In hematological malignancies, there are numerous examples of lymphocyte developmental genes playing a role in cancer formation. In this article, we discuss how processes of fetal organogenesis are also operant in lung tumorigenesis. We first review four pathways important in lung cancer (MYC, Hedgehog, Rb and Wnt) and describe the experimental evidence linking them to lung development. Then, we review genome-wide analysis approaches of both RNA (gene expression profiling) and DNA (copy number alterations) and how they have uncovered links between lung cancer and fetal lung development. Finally, the recent discovery of three closely linked developmental transcription factors, which are co-amplified as cooperating lung oncogenes, is discussed. We suggest that inhibition of the fetal developmental pathways selectively reactivated in cancer cells is a research area of interest for novel anti-cancer therapies in light of the presumed low toxicity of such therapies to the nearby normal adult cells.
机译：在血液系统恶性肿瘤中，有许多淋巴细胞发育基因在癌症形成中起作用的例子。在本文中，我们讨论胎儿器官发生的过程在肺肿瘤发生中也如何运作。我们首先回顾了对肺癌重要的四种途径（MYC，刺猬，Rb和Wnt），并描述了将它们与肺部发育联系起来的实验证据。然后，我们回顾了RNA（基因表达谱）和DNA（拷贝数变化）的全基因组分析方法，以及它们如何揭示肺癌与胎儿肺发育之间的联系。最后，讨论了三个紧密相连的发育转录因子的最新发现，它们被共同放大为协同肺癌基因。我们建议，鉴于这种疗法对附近正常成年细胞的低毒性，抑制在癌细胞中选择性重新激活的胎儿发育途径是新型抗癌疗法的研究重点。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号