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首页> 外文期刊>Cellular immunology >Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells.
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Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells.

机译：THP-1细胞中热激蛋白27对脂多糖诱导的炎症反应的调节。

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摘要

HSP27 is a member of the small HSP family which has been linked to different signaling pathways regulating critical cellular functions. But the role of HSP27 in LPS-induced inflammatory signaling pathways is still unclear. In the present study, both overexpression and RNA interference experiments indicated that HSP27 increased LPS-induced expression of iNOS and COX-2 and release of NO/PGE2 through enhancing NF-kappaB but not MAPK activation. The effects of HSP27 on LPS-induced iNOS/COX-2 expression and relative signaling cascade were closely related with the phosphorylation of HSP27. Further studies have shown that HSP27-regulated LPS-induced activation of NF-kappaB by interacting with TRAF6 and increasing the association of TRAF6-IKKgamma. This could be a probable mechanism by which HSP27 modulates LPS-induce inflammatory signaling pathways. Thus, HSP27 may play a potential role in regulating inflammatory responses in immunologic system.
机译：HSP27是小型HSP家族的成员，该家族已与调节关键细胞功能的不同信号通路相连。但是，HSP27在LPS诱导的炎症信号通路中的作用仍不清楚。在本研究中，过表达和RNA干扰实验均表明HSP27通过增强NF-κB而不是MAPK激活来增加LPS诱导的iNOS和COX-2的表达以及NO / PGE2的释放。 HSP27对LPS诱导的iNOS / COX-2表达及相关信号级联反应的影响与HSP27的磷酸化密切相关。进一步的研究表明，HSP27通过与TRAF6相互作用并增加TRAF6-IKKgamma的结合来调节LPS诱导的NF-κB活化。这可能是HSP27调节LPS诱导炎症信号通路的可能机制。因此，HSP27可能在调节免疫系统的炎症反应中起潜在作用。

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