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首页> 外文期刊>Cellular immunology >Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?
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Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?

机译：继发性异源登革热感染的风险：免疫调节和炎症之间的不平衡？

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摘要

Increased serum levels of cytokines released by cells of the immune response have been detected in patients suffering from dengue disease. Likewise, secondary infections by a different dengue virus serotype result in a highest risk of development of the severe dengue disease. Both findings suggest that the memory immune response is one of the key players in the pathogenesis of this disease. Here we take advantage of the particular Cuban epidemiological situation in dengue to analyze a broad spectrum of cell-mediated immune response mediators at mRNA and protein level. Evidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe dengue cases in the latter case.
机译：在患有登革热疾病的患者中已经检测到由免疫反应的细胞释放的血清细胞因子水平升高。同样，不同登革热病毒血清型的继发感染导致发生严重登革热疾病的风险最高。两项发现均表明记忆免疫反应是该病发病机理的关键因素之一。在这里，我们利用登革热中特定的古巴流行病学情况，在mRNA和蛋白质水平上分析了多种细胞介导的免疫反应介质。在异源登革热病毒再次攻击中发现了同源性（TGF-beta，IL-10）与促炎性模式（IFN-γ，TNF-alpha）的调节性免疫模式的证据，表明可能与更高的发病率相关严重的登革热病例在后一种情况下。

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