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The role of activation-induced cell death in the higher onset of spontaneous apoptosis of NK cell subsets in patients with metastatic epithelial cancer.

机译:转移性上皮癌患者中,活化诱导的细胞死亡在NK细胞亚群自发性凋亡较高发作中的作用。

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To address the question whether the higher onset of apoptosis of circulating NK cell subsets might be activation induced in cancer patients, surface expression of NKG2D and serum (s) levels of MHC class I chain-related (MIC) proteins in relation to apoptosis marker and CD95 expression on NK cells were evaluated. Patients showed a significantly higher onset of spontaneous apoptosis of CD56dim NK cells. No difference in the CD95 expression could be detected between patients and normal controls (NCs). Patients' CD56bright NK cells demonstrated a higher expression of NKG2D compared to CD56dim NK cells. The sMICB levels showed a higher level in patients versus NCs. No correlation between sMIC protein levels with both NKG2D expression and onset of spontaneous apoptosis of NK cell subsets was found. Our data suggest that the higher onset of apoptosis of circulating NK cell subsets of patients is not triggered by activation-induced cell death.
机译:为了解决是否可能在癌症患者中诱导激活循环NK细胞亚群凋亡的更高发作的问题,NKG2D的表面表达和血清MHC I类链相关(MIC)蛋白与凋亡标记和评价了NK细胞上的CD95表达。患者显示出CD56dim NK细胞的自发凋亡明显更高。患者和正常对照(NC)之间CD95表达没有差异。与CD56dim NK细胞相比,患者的CD56bright NK细胞表现出更高的NKG2D表达。与NCs相比,患者的sMICB水平更高。没有发现sMIC蛋白水平与NKG2D表达和NK细胞亚群的自发凋亡均相关。我们的数据表明,激活的细胞死亡不会触发患者循环NK细胞亚群发生更高的凋亡。

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