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首页> 外文期刊>Cellular immunology >Exogenous dendritic cell homing to draining lymph nodes can be boosted by mast cell degranulation.
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Exogenous dendritic cell homing to draining lymph nodes can be boosted by mast cell degranulation.

机译：肥大细胞脱粒可促进外源性树突状细胞归巢至引流淋巴结。

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摘要

Dendritic cells (DCs), as potent antigen presenting cells, are increasingly used for immunotherapeutic approaches, predominantly in oncology. Low efficiency of injected Ag-pulsed DC homing to draining lymph nodes (DLNs) is one of the factors that affect the efficacy of therapy. As Langerhans cell emigration was enhanced after skin mast cell degranulation, we investigated the effect of local mast cell activation on exogenous bone marrow-derived DCs (BM-DCs) homing to DLNs. Product of activated MC/9 mast cells enhanced chemotaxis of BM-DCs to CCL21 in vitro. Intradermal injection of compound 48/80 (c48/80) induced local skin mast cell obvious degranulation and boosted exogenous BM-DC homing to DLNs. Both Ag-specific lymphocyte proliferation and TH1/TH2 cytokine production increased after HBsAg-pulsed BM-DC was injected into c48/80 pretreated mice. These results suggest that transferred DC homing to DLNs promoted by local mast cell degranulation may have potential application to improve DC-based immunotherapy.
机译：树突状细胞（DCs）作为有效的抗原呈递细胞，越来越多地用于免疫治疗方法，主要是在肿瘤学中。注射Ag脉冲DC归巢至引流淋巴结（DLN）的效率低是影响治疗效果的因素之一。由于皮肤肥大细胞脱粒后朗格汉斯细胞迁移增强，我们研究了局部肥大细胞活化对归巢于DLN的外源性骨髓衍生DC（BM-DC）的影响。激活的MC / 9肥大细胞产物在体外增强了BM-DC对CCL21的趋化性。皮内注射化合物48/80（c48 / 80）引起局部皮肤肥大细胞明显脱颗粒，并促进外源BM-DC归巢至DLN。 HBsAg脉冲的BM-DC注射到c48 / 80预处理小鼠中后，Ag特异性淋巴细胞增殖和TH1 / TH2细胞因子的产生均增加。这些结果表明，将DC归巢转移到局部肥大细胞脱粒促进的DLN中，可能具有改善基于DC的免疫疗法的潜在应用。

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