• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cellular immunology >Synthesis and immunological activities of novel agonists of toll-like receptor 9.
【24h】

Synthesis and immunological activities of novel agonists of toll-like receptor 9.

机译：Toll样受体9新型激动剂的合成及免疫活性

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Novel agonists of TLR9 with two 5'-ends and synthetic immune stimulatory motifs, referred to as immune modulatory oligonucleotides (IMOs) are potent agonists of TLR9. In the present study, we have designed and synthesized 15 novel IMOs by incorporating specific chemical modifications and studied their immune response profiles both in vitro and in vivo. Analysis of the immunostimulatory profiles of these IMOs in human and NHP cell-based assays suggest that changes in the number of synthetic immunostimulatory motifs gave only a subtle change in immune stimulation of pDCs as indicated by IFN-alpha production and pDC maturation while the addition of self-complementary sequences produced more dramatic changes in both pDC and B cell stimulation. All IMOs induced cytokine production in vivo immediately after administration in mice. Representative compounds were also compared for the ability to stimulate cytokine production in vivo (IFN-alpha and IP-10) in rhesus macaques after intra-muscular administration.
机译：具有两个5'端和合成的免疫刺激基序的TLR9的新型激动剂，被称为免疫调节性寡核苷酸（IMO），是TLR9的有效激动剂。在本研究中，我们通过结合特定的化学修饰设计并合成了15种新型IMO，并在体内和体外研究了它们的免疫应答特性。在基于人和NHP细胞的分析中对这些IMO的免疫刺激谱进行分析表明，合成免疫刺激基序数量的变化仅对pDC的免疫刺激产生了细微变化，如IFN-α产生和pDC成熟所表明的，自身互补序列在pDC和B细胞刺激中产生了更显着的变化。在小鼠中施用后，所有IMO立即在体内诱导细胞因子的产生。肌肉注射后，还比较了代表性化合物刺激恒河猴体内体内细胞因子产生的能力（IFN-α和IP-10）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号