Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae.

Teng F; Slavik V; Duffy KE; San Mateo L; Goldschmidt R

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Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae.

机译：Toll样受体3参与了对不可分型流感嗜血杆菌的气道上皮细胞反应。

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Nontypeable Haemophilus influenzae (NTHi) is the etiological agent most frequently associated with bacterial exacerbations of chronic obstructive pulmonary disease (COPD). The present work shows that NTHi strains induced in primary normal human bronchial epithelial cells (NHBE) a cytokine/chemokine response in which CCL-5 and CXCL-10 were predominant. Production of both cytokines was inhibited by an anti-TLR3 monoclonal antibody (mAb) in a dose-dependent manner, but not by control human IgG4 antibodies, thus suggesting a TLR3-dependency of the NTHi stimulation. BEAS-2B, an immortalized human bronchial epithelial cell line, also showed a similar NTHi-induced response that was inhibited by the anti-TLR3 mAb. A BEAS-2B cell line stably expressing TLR3 siRNA showed significantly reduced cytokine/chemokine responses to NTHi stimulation, confirming the role of TLR3 in the response. These results indicate that TLR3 is a key component in the response of human bronchial epithelial cells to NTHi, and suggest that cognate neutralizing mAbs might be a useful therapeutic tool to regulate the inflammatory response.

机译：非分型流感嗜血杆菌（NTHi）是最常与慢性阻塞性肺疾病（COPD）细菌加重相关的病原体。目前的工作表明，NTHi菌株在原代正常人支气管上皮细胞（NHBE）中诱导了以CCL-5和CXCL-10为主的细胞因子/趋化因子反应。抗TLR3单克隆抗体（mAb）以剂量依赖的方式抑制了两种细胞因子的产生，但对照人IgG4抗体则没有，因此暗示了NTHi刺激的TLR3依赖性。 BEAS-2B是一种永生化的人支气管上皮细胞系，也显示出类似的NTHi诱导反应，该反应被抗TLR3 mAb抑制。稳定表达TLR3 siRNA的BEAS-2B细胞系显示出对NTHi刺激的细胞因子/趋化因子应答显着降低，证实了TLR3在应答中的作用。这些结果表明TLR3是人支气管上皮细胞对NTHi应答的关键成分，并表明同源中和mAbs可能是调节炎症反应的有用治疗工具。

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《Cellular immunology》 |2010年第2期|共7页
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Teng F; Slavik V; Duffy KE; San Mateo L; Goldschmidt R;
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正文语种 eng
中图分类细胞生物学;医学免疫学;
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1. Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae. [J] . Teng F, Slavik V, Duffy KE, Cellular immunology . 2010,第2期

机译：Toll样受体3参与了对不可分型流感嗜血杆菌的气道上皮细胞反应。
2. Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae. [J] . Lazou-Ahren I, Bjartell A, Egesten A, The Journal of Infectious Diseases . 2001,第7期

机译：脂多糖结合蛋白通过不可分型的流感嗜血杆菌增加toll样受体4依赖性激活。
3. Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear [J] . Sung K. Moon, Jeong-Im Woo, Haa-Yung Lee, Infection and immunity . 2007,第7期

机译：Toll样受体2依赖性NF-κB激活涉及内耳螺旋韧带纤维细胞中不可分型流感嗜血杆菌诱导的单核细胞趋化蛋白1上调。
4. Upregulation of PGRPs by chemically synthesized pathogen-associated molecular patterns via Toll-like receptors, NODI and NOD2 in oral epithelial cells [C] . Akiko Uehara, Yumiko Sugawara, Shoichiro Kurat International Symposium for Interface Oral Health Science . 2005

机译：通过在口腔上皮细胞中通过沟状受体，NODI和NOD2通过化学合成的病原体相关分子模式上调PGRP
5. Internalization and Trafficking of Nontypeable Haemophilus influenzae in Human Respiratory Epithelial Cells and the Roles of IgA1 Proteases for Optimal Internalization and Persistence. [D] . Clementi, Cara Franklin. 2013

机译：人类呼吸道上皮细胞中非典型流感嗜血杆菌的内在化和贩运以及IgA1蛋白酶对最佳内在化和持久性的作用。
6. Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear [O] . Sung K. Moon, Jeong-Im Woo, Haa-Yung Lee, 2007

机译：Toll样受体2依赖性NF-κB激活涉及内耳螺旋韧带纤维细胞中不可分型流感嗜血杆菌诱导的单核细胞趋化蛋白1上调。
7. Toll-Like Receptor 2-Dependent NF-κB Activation Is Involved in Nontypeable Haemophilus influenzae-Induced Monocyte Chemotactic Protein 1 Up-Regulation in the Spiral Ligament Fibrocytes of the Inner Ear▿ [O] . Moon, Sung K., Woo, Jeong-Im, Lee, Haa-Yung, 2007

机译：Toll样受体2依赖性NF-κB激活涉及内耳螺旋韧带纤维细胞中不可分型的流感嗜血杆菌诱导的单核细胞趋化蛋白1上调▿
8. Postexposure Application of Fas Receptor Small-Interfering RNA to Suppress Sulfur Mustard-Induced Apoptosis in Human Airway Epithelial Cells: Implication for a Therapeutic Approach. [R] . B. Benton B. M. Keyser D. K. Andres E. Nealley W. W. Holmes 2013

机译：暴露应用Fas受体小干扰RNa抑制硫芥诱导人气道上皮细胞凋亡：治疗方法的意义。

Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae.

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