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首页> 外文期刊>Cell cycle >Beyond heterochromatin: SIR2 inhibits the initiation of DNA replication.
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Beyond heterochromatin: SIR2 inhibits the initiation of DNA replication.

机译：超越异染色质：SIR2抑制DNA复制的启动。

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Over the last decade, data have accumulated that support a role for chromatin structure in regulating the initiation of DNA replication and its timing during S-phase. However, the mechanisms underlying how chromatin structure influences replication initiation are not always understood. For example, in Drosophila histone acetylation at the ACE3 and Ori-beta sequences near one of the amplified chorion loci is correlated with ORC (origin recognition complex) binding and re-replication of this locus. Whether histone acetylation promotes ORC binding or some later step in replication is not known. In yeast, hypo-acetylated heterochromatin and telomeric regions replicate late in S-phase but the mechanisms that restrict the initiation of replication at these loci are not fully understood. Nonetheless, it seems likely that histone acetylation and other types of histone modification will significantly impact DNA replication. A recent study published in Molecular Cell reveals a role for the conserved NAD(+)-dependent histone deacetylase, Sir2, in inhibiting the assembly of the multiprotein complex necessary for the selection and activation of yeast replication origins. Here, we highlight key conclusions from this study, place them in perspective with earlier work, and outline important future questions.
机译：在过去的十年中，积累的数据支持染色质结构在调节DNA复制的起始及其在S期的时序方面的作用。但是，并不总是了解染色质结构如何影响复制起始的潜在机制。例如，在果蝇中，在扩增的绒毛膜基因座之一附近的ACE3和Ori-β序列处的组蛋白乙酰化与该基因座的ORC（起源识别复合体）结合和重复相关。组蛋白乙酰化是否促进ORC结合或复制中的某些后续步骤尚不清楚。在酵母中，次乙酰化的异染色质和端粒区域在S期晚期复制，但在这些基因座上限制复制起始的机制尚不完全清楚。尽管如此，组蛋白乙酰化和其他类型的组蛋白修饰似乎将显着影响DNA复制。最近在《分子细胞》上发表的一项研究揭示了保守的NAD（+）依赖的组蛋白脱乙酰基酶Sir2在抑制选择和激活酵母复制起点所需的多蛋白复合物装配中的作用。在这里，我们重点介绍了这项研究的关键结论，将其与早期工作相结合，并概述了未来的重要问题。

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