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首页> 外文期刊>Cellular immunology >Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.
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Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.

机译：心理压力与乳腺癌患者中髓样抑制细胞水平的改变有关。

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Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myeloid-derived suppressor cells (MDSC) compared to patients with lower stress. PBMC from 16 patients with high stress (n = 8) or with low stress (n = 8) after surgery as measured by the Impact of Event Scale (IES) questionnaire were evaluated for the presence of MDSC. Patients with higher IES scores had significantly elevated salivary cortisol levels (P = 0.013; 13 mug/dl vs. 9.74 mug/dl). Levels of IL-1Ralpha were also significantly elevated in the higher IES group (45.09 pg/ml vs. 97.16 pg/ml; P = 0.010). IP 10, G-CSF, and IL-6 were all higher in the high stress group although not to a significant degree. Flow cytometric analysis for CD33+/HLA-DR-neg/CD15+/CD11b+ MDSC revealed increased MDSC in patients with lower IES scores (P = 0.009). CD11b+/CD15+ cells constituted 9.4% of the CD33+/HLA DR-neg cell population in patients with high IES, vs. 27.3% in patients with low IES scores. Additional analyzes of the number of stressful events that affected the patients in addition to their cancer diagnosis revealed that this type of stress measure correlated with elevated levels of MDSC (P = 0.064). These data indicate the existence of a complex relationship between stress and immune function in breast cancer patients.
机译：我们的小组在一项随机临床试验中表明，通过心理干预减少II期和III期乳腺癌患者的压力，可以增强免疫功能，减少复发并改善总体生存率。我们假设与压力较低的患者相比，压力较高的患者的髓样抑制细胞（MDSC）会有改变。通过事件影响量表（IES）问卷调查，对16名高压力（n = 8）或低压力（n = 8）手术后​​患者的PBMC进行了MDSC评估。 IES评分较高的患者唾液皮质醇水平显着升高（P = 0.013; 13杯/分升与9.74杯/分升）。在较高的IES组中，IL-1Ralpha的水平也显着升高（45.09 pg / ml与97.16 pg / ml; P = 0.010）。 IP 10，G-CSF和IL-6在高应激组中均较高，尽管程度不明显。 CD33 + / HLA-DR-neg / CD15 + / CD11b + MDSC的流式细胞仪分析显示，IES评分较低的患者MDSC升高（P = 0.009）。 IES高的患者中CD11b + / CD15 +细胞占CD33 + / HLA DR-neg细胞群体的9.4％，而IES得分低的患者中CD11b + / CD15 +细胞占27.3％。除癌症诊断外，对影响患者的压力事件数量的其他分析还显示，这种压力测量与MDSC水平升高相关（P = 0.064）。这些数据表明在乳腺癌患者中压力与免疫功能之间存在复杂的关系。

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