Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells.

Tanaka S; Sakamoto H

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Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells.

机译：D-阿洛糖对树突状细胞内吞活性和随后的T细胞刺激的影响。

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We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, which had been exposed to BCG in D-allose-supplemented medium, induced apoptosis of CD4(+) T cells in a manner dependent on D-allose concentration. After the MLR, DCs cultured in the medium with D-allose expressed less CD40 and more Fas ligands than those cultured without D-allose. It was suggested that the functions of DCs, internalization, processing and the subsequent antigen presentation to T cells, are down-regulated via the action of d-allose.

机译：我们检查了稀有糖D-阿洛糖（6-碳单糖）对树突状细胞（DC）的内吞作用和T细胞刺激的影响。 DC在含D-阿洛糖的培养基中对BCG-抗-BCG免疫复合物的内吞作用明显降低。与DC的T细胞共培养（混合白细胞反应，MLR）已暴露于B-葡萄糖补充培养基中的BCG中，诱导CD4（+）T细胞凋亡，其方式取决于D-乳糖的浓度。在MLR之后，与不含D-阿洛糖的培养物相比，在含D-阿洛糖的培养基中培养的DC表达的CD40少，Fas配体更多。提示DC的功能，内在化，加工以及随后的抗原呈递给T细胞，是通过d-阿糖的作用下调的。

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《Cellular immunology》 |2011年第1期|共6页
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Tanaka S; Sakamoto H;
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正文语种 eng
中图分类细胞生物学;
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1. Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells. [J] . Tanaka S, Sakamoto H Cellular immunology . 2011,第1期

机译：D-阿洛糖对树突状细胞内吞活性和随后的T细胞刺激的影响。
2. Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells. [J] . Tourkova IL, Shurin GV, Wei S, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第12期

机译：小rho GTPases介导肿瘤诱导的树突状细胞内吞活性的抑制。
3. Glucocorticoids increase the endocytic activity of human dendritic cells. [J] . Piemonti L, Monti P, Allavena P, International immunology. . 1999,第9期

机译：糖皮质激素增加人树突状细胞的内吞活性。
4. Regulatory effects of α-melanocyte stimulating hormone on the development and function of dendritic cells [C] . Ye-Ping Tian, Juan Shen, Ming-Hui Zhang Chinese Peptide Symposium . 2005

机译：α-黑素细胞刺激激素对树突细胞发育和功能的调节作用
5. The endocytic requirements for cross presentation by human dendritic cells. [D] . Chatterjee, Bithi. 2012

机译：人树突状细胞交叉呈递的内吞要求。
6. Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells. [O] . T P Levine, B M Chain 1992

机译：抗原呈递细胞的内吞作用：树突状细胞与其他抗原呈递细胞一样具有内吞活性。
7. Endocytosis by antigen presenting cells: dendritic cells are as endocytically active as other antigen presenting cells. [O] . Levine, T P, Chain, B M 1992

机译：抗原呈递细胞的内吞作用：树突状细胞与其他抗原呈递细胞一样具有内吞活性。
8. Stimulation of Polymorphonuclear Leukocyte Bactericidal Activity by Supernatants of Activated Human Mononuclear Cells. [R] . Cross, A. S., Lowell, G. H. 1978

机译：激活人单核细胞上清对刺激多形核白细胞杀菌活性的研究。

Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells.

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