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首页> 外文期刊>Cellular immunology >Perinatal supplementation with thymoquinone improves diabetic complications and T cell immune responses in rat offspring.
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Perinatal supplementation with thymoquinone improves diabetic complications and T cell immune responses in rat offspring.

机译：围产期补充胸腺醌可改善大鼠后代的糖尿病并发症和T细胞免疫反应。

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BACKGROUND: Epidemiological studies have shown that the offspring of mothers who experience diabetes mellitus during pregnancy are seven times more likely to develop health complications later in life compared to offspring born to nondiabetic mothers. AIM OF THE STUDY: We investigated whether supplementation with a natural antioxidant (thymoquinone; TQ) in female rats with streptozotocin (STZ)-induced gestational diabetes (GD) improved diabetic complications and T cell immune responses in their offspring. METHODS: Three groups of female rats were tested: nondiabetics, diabetics treated with TQ during pregnancy and lactation periods and diabetics that were not treated with TQ (n=10 female rats in each group). RESULTS: Our data demonstrated a significant decrease in the numbers of neonates born to diabetic rats compared with those born to control rats. GD led to macrosomic pups with several postpartum complications, such as a significant increase in plasma levels of the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha (but not of IL-10); a marked decrease in the plasma level of IL-2; a marked reduction in the proliferative capacity of superantigen (SEB)-stimulated T-lymphocytes; and an obvious reduction in the number of circulating and thymus homing T cells. TQ supplementation of diabetic mothers during pregnancy and lactation periods had an obvious and significant effect on the number and mean body weight of neonates. Furthermore, TQ significantly restored the IL-2 level and T cell proliferation and subsequently rescued both circulating and thymus homing T cells in the offspring. CONCLUSIONS: Our data suggest that nutritional supplementation of GD mothers with the natural antioxidant TQ during pregnancy and lactation periods improves diabetic complications and maintains an efficient T cell immune response in their offspring, providing a protective effect in later life.
机译：背景：流行病学研究表明，与非糖尿病母亲所生的后代相比，母亲在怀孕期间罹患糖尿病的后代在生命后期出现健康并发症的可能性要高7倍。研究目的：我们研究了在链脲佐菌素（STZ）诱导的妊娠糖尿病（GD）的雌性大鼠中补充天然抗氧化剂（thymoquinone; TQ）是否能改善其后代的糖尿病并发症和T细胞免疫反应。方法：对三组雌性大鼠进行了测试：非糖尿病，在妊娠和哺乳期接受TQ治疗的糖尿病患者以及未接受TQ治疗的糖尿病患者（每组10只雌性大鼠）。结果：我们的数据表明，与对照组大鼠相比，糖尿病大鼠出生的新生儿数量显着减少。 GD导致产后幼犬出现一些产后并发症，例如促炎性细胞因子IL-1beta，IL-6和TNF-α（而非IL-10）的血浆水平显着升高; IL-2的血浆水平明显下降;超级抗原（SEB）刺激的T淋巴细胞的增殖能力显着降低;并且循环和胸腺归巢的T细胞数量明显减少。妊娠和哺乳期补充糖尿病母亲的TQ对新生儿的数量和平均体重有明显和显着的影响。此外，TQ显着恢复了IL-2水平和T细胞增殖，随后挽救了后代中循环的和胸腺归巢的T细胞。结论：我们的数据表明，在妊娠和哺乳期以自然抗氧化剂TQ补充GD母亲的营养可改善糖尿病并发症，并在其后代中维持有效的T细胞免疫反应，从而在以后的生活中起到保护作用。

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