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首页> 外文期刊>Radiology >Experimental pyelonephritis in piglets: diagnosis with MR imaging.
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Experimental pyelonephritis in piglets: diagnosis with MR imaging.

机译：仔猪的实验性肾盂肾炎：MR成像诊断。

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PURPOSE: To compare findings at magnetic resonance (MR) imaging with those at histopathologic examination in the detection of experimentally induced pyelonephritis in piglets. MATERIALS AND METHODS: MR imaging was performed in 23 piglets with and nine piglets without experimentally induced pyelonephritis. Escherichia coli were injected into the bladder of the 23 piglets with surgically created vesicoureteral reflux. Imaging was performed with unenhanced and contrast material-enhanced T1-weighted and fast multiplanar inversion-recovery (IR) and fast spinecho T2-weighted sequences. MR images and pathologic findings were reviewed independently by two pediatric radiologists and a pathologist, respectively, in a blinded fashion. RESULTS: Sixty-four kidneys and 192 renal zones were evaluated. Coronal gadolinium-enhanced fast multiplanar IR imaging was the only sequence that was sensitive and specific for the diagnosis of pyelonephritis. For the two reviewers, respectively, sensitivity was 85% (n = 75) and 92% (n = 81) of 88 histopathologically positive zones and specificity was 95% (n = 99) and 94% (n = 98) of 104 pathologically negative zones. Findings at gadolinium-enhanced fast multiplanar IR imaging were not statistically different from findings at histopathologic examination in the detection of pyelonephritis. Interobserver reproducibility for the contrast-enhanced fast multiplanar IR sequence was excellent (kappa statistic = 0.82 and 0.90, respectively, for interpretation of a renal zone and of a kidney). CONCLUSION: Contrast-enhanced fast multiplanar IR imaging is a sensitive and specific test for detection of experimental pyelonephritis in this piglet model.
机译：目的：比较在磁共振成像和组织病理学检查中发现的实验性仔猪肾盂肾炎的发现。材料与方法：MR成像在23头有仔猪和9头没有实验性肾盂肾炎的仔猪中进行。将大肠埃希氏菌通过手术产生的膀胱输尿管反流注射入23只仔猪的膀胱。使用未增强和对比剂增强的T1加权和快速多平面反转恢复（IR）和快速脊柱T2加权序列进行成像。两名儿科放射科医生和一名病理学家分别以盲法对MR图像和病理结果进行了独立审查。结果：评估了64个肾脏和192个肾区。冠状g增强的多平面快速IR成像是对肾盂肾炎的诊断具有敏感性和特异性的唯一序列。对于这两个审稿人，在88个组织病理学阳性区域中，敏感性分别为85％（n = 75）和92％（n = 81），特异性在104个病理学阳性区域中分别为95％（n = 99）和94％（n = 98）。负面区域。 lin增强的快速多平面IR成像的发现与肾盂肾炎的组织病理学检查无统计学差异。对比增强的快速多平面IR序列的观察者间可重复性极佳（kappa统计量分别为0.82和0.90，用于解释肾区和肾脏）。结论：对比增强的快速多平面红外成像是该猪模型中检测实验性肾盂肾炎的灵敏且特异的测试。

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