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首页> 外文期刊>Radiology >Quantitative MR imaging of brain iron: a postmortem validation study.
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Quantitative MR imaging of brain iron: a postmortem validation study.

机译：脑铁的定量MR成像：事后验证研究。

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PURPOSE: To investigate the relationship between transverse relaxation rates R2 and R2*, the most frequently used surrogate markers for iron in brain tissue, and chemically determined iron concentrations. MATERIALS AND METHODS: This study was approved by the local ethics committee, and informed consent was obtained from each individual's next of kin. Quantitative magnetic resonance (MR) imaging was performed at 3.0 T in seven human postmortem brains in situ (age range at death, 38-81 years). Following brain extraction, iron concentrations were determined with inductively coupled plasma mass spectrometry in prespecified gray and white matter regions and correlated with R2 and R2* by using linear regression analysis. Hemispheric differences were tested with paired t tests. RESULTS: The highest iron concentrations were found in the globus pallidus (mean +/- standard deviation, 205 mg/kg wet mass +/- 32), followed by the putamen (mean, 153 mg/kg wet mass +/- 29), caudate nucleus (mean, 92 mg/kg wet mass +/- 15), thalamus (mean, 49 mg/kg wet mass +/- 11), and white matter regions. When all tissue samples were considered, transverse relaxation rates showed a strong linear correlation with iron concentration throughout the brain (r(2) = 0.67 for R2, r(2) = 0.90 for R2*; P < .001). In white matter structures, only R2* showed a linear correlation with iron concentration. Chemical analysis revealed significantly higher iron concentrations in the left hemisphere than in the right hemisphere, a finding that was not reflected in the relaxation rates. CONCLUSION: Because of their strong linear correlation with iron concentration, both R2 and R2* can be used to measure iron deposition in the brain. Because R2* is more sensitive than R2 to variations in brain iron concentration and can detect differences in white matter, it is the preferred parameter for the assessment of iron concentration in vivo.
机译：目的：研究横向弛豫率R2和R2 *（脑组织中铁的最常用替代标志物）与化学测定的铁浓度之间的关系。材料与方法：该研究得到当地伦理委员会的批准，并从每个人的近亲获得知情同意。定量磁共振（MR）成像是在7个人体死后大脑中于3.0 T进行的（死亡年龄范围为38-81岁）。脑提取后，通过电感耦合等离子体质谱法测定预先指定的灰和白质区域中的铁浓度，并通过线性回归分析将其与R2和R2 *相关。用配对t检验对半球差异进行了检验。结果：在苍白球中发现了最高的铁浓度（平均+/-标准偏差，205 mg / kg湿质量+/- 32），其次是壳核（平均153 mg / kg湿质量+/- 29）。 ，尾状核（平均92 mg / kg湿质量+/- 15），丘脑（平均49 mg / kg湿质量+/- 11）和白质区域。当考虑所有组织样本时，横向弛豫率显示出与整个大脑中铁浓度的强线性相关性（R2的r（2）= 0.67，R2 *的r（2）= 0.90; P <.001）。在白质结构中，只有R2 *与铁浓度呈线性关系。化学分析表明，左半球的铁浓度比右半球的铁浓度高得多，这一发现并未反映在弛豫率中。结论：由于R2和R2 *与铁浓度呈强线性关系，因此可用于测量脑中铁的沉积。因为R2 *对脑铁浓度的变化比R2更敏感，并且可以检测白质的差异，所以它是评估体内铁浓度的首选参数。

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