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Pulmonary abnormalities and PET data analysis: a retrospective study.

机译:肺部异常和PET数据分析:一项回顾性研究。

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PURPOSE: To assess methods of standard uptake ratio (SUR) calculation with 2-deoxy-2-[fluorine-18]fluoro-D-glucose (FDG) positron emission tomography (PET) in indeterminate focal pulmonary abnormalities. MATERIALS AND METHODS: One hundred ninety-seven adult patients with indeterminate pulmonary abnormalities had complete FDG PET data, consistent methods of data acquisition, and definitive diagnosis with tissue biopsy or negative 2-year follow-up findings. PET studies were evaluated by using SURs calculated with the average or maximum region-of-interest pixel value in the numerator and with weight, lean body mass, or body surface area in the denominator. RESULTS: One hundred twenty malignant lesions and 77 benign processes were identified. Receiver operating characteristic (ROC) curve areas were statistically significantly larger with the average rather than the maximum pixel value in the calculation of the SUR for any of the three denominators (P < or = .05). SURs calculated with weight versus lean body mass versus body surface area in the denominator showed no statistically significant difference in ROC curve areas. CONCLUSION: SURs determined by using average pixel values provide statistically significant improvement in ROC curve areas over those determined by using maximum pixel values. Weight, lean body mass, and body surface area in the denominator of the SUR calculation provide equivalent ROC curve areas and are therefore equivalent in accuracy in this population.
机译:目的:评估在不确定的局灶性肺部异常中使用2-脱氧-2- [氟-18]氟-D-葡萄糖(FDG)正电子发射断层显像(PET)进行标准摄取比(SUR)计算的方法。材料与方法:一百七十七例不确定的肺部异常的成年患者具有完整的FDG PET数据,一致的数据采集方法以及明确的组织活检或2年随访结果阴性的诊断。通过使用SUR评估PET研究,该SUR是用分子中的平均或最大关注区域像素值以及分母中的重量,瘦体重或体表面积计算得出的。结果:鉴定出120个恶性病变和77个良性过程。对于三个分母中的任何一个,在SUR的计算中,接收器工作特性(ROC)曲线面积在统计学上均显着大于平均值而不是最大像素值(P <或= 0.05)。用分母中的重量对瘦体重对身体表面积计算的SUR在ROC曲线面积上没有统计学上的显着差异。结论:通过使用平均像素值确定的SUR与通过使用最大像素值确定的SUR相比,在ROC曲线区域上具有统计学上的显着改善。 SUR计算的分母中的重量,瘦体重和身体表面积提供了等效的ROC曲线面积,因此在该总体中,精度是等效的。

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