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Focused US system for MR imaging-guided tumor ablation.

机译：聚焦美国系统，用于MR成像引导的肿瘤消融。

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摘要

PURPOSE: To measure the performance characteristics of a focused ultrasound (US) system for magnetic resonance (MR) imaging-guided tumor ablation. MATERIALS AND METHODS: The authors constructed a focused US system for MR imaging-guided tumor ablation. The location of the heated region and thermal dose were monitored with temperature-sensitive MR images obtained in phantoms and rabbit skeletal muscle after application of each sonic pulse. RESULTS: The region heated by the focused ultrasound beam was within 1 mm of that observed on temperature-sensitive fast gradient-echo MR images of in vivo rabbit skeletal muscle. Analysis of heat flow and the rate of coagulation necrosis provided an estimate of the size of the ablated region that was in agreement with experimental findings. CONCLUSION: MR imaging provides target definition and control for thermal therapy in regions of variable perfusion or in tissues that are not well characterized.
机译：目的：测量聚焦超声（US）系统在磁共振（MR）成像引导下的肿瘤消融的性能特征。材料与方法：作者构建了用于MR成像引导的肿瘤消融的聚焦美国系统。施加每个声波脉冲后，用在体模和兔骨骼肌中获得的对温度敏感的MR图像监控加热区域的位置和热剂量。结果：聚焦超声束加热的区域在体内兔骨骼肌对温度敏感的快速梯度回波MR图像上观察到的区域不到1毫米。对热流和凝血坏死速率的分析提供了对烧蚀区域大小的估计，该估计与实验结果相符。结论：MR成像为可变灌注区域或特征不明确的组织中的热疗提供了目标定义和控制。

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