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首页> 外文期刊>Cellular immunology >Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice
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Therapeutic potential of Lactobacillus plantarum CJLP133 for house-dust mite-induced dermatitis in NC/Nga mice

机译：植物乳杆菌CJLP133对屋尘螨诱发的皮炎在NC / Nga小鼠中的治疗潜力

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摘要

Lactobacillus plantarum CJLP133 was isolated from Kimchi, a Korean fermented food, and its potential to improve mouse atopic dermatitis after onset was studied. Dermatitis was developed through house dust-mite extract application onto NC/Nga mice, and then CJLP133 feeding was started. CJLP133 suppressed dermatitis-like skin lesions and decreased high serum IgE levels through balancing between IL-4 and IFN-γ in serum. CJLP133 diminished skin thickening, mast cell accumulation into inflamed site, and lymph node enlargement. In lymph node cells, CJLP133 repressed secretion of T cell cytokines such as IFN-γ, IL-4, IL-5, and IL-10. However, CJLP133 decreased ratios of IFN-γ and IL-5 to IL-10 in lymph node cells, while it did not decrease ratios of IL-4 and IL-5 to IFN-γ. Conclusively, CJLP133 exhibited therapeutic potential for atopic dermatitis in mice through orderly increment of type 1 helper T cell activation and regulatory T cell activation. These results suggest that CJLP133 could treat human atopic dermatitis.
机译：从朝鲜发酵食品泡菜中分离出植物乳杆菌CJLP133，并研究了其在发病后改善小鼠特应性皮炎的潜力。通过将室内尘螨提取物应用到NC / Nga小鼠上而发展为皮炎，然后开始CJLP133喂养。 CJLP133通过平衡血清中的IL-4和IFN-γ抑制了类皮炎皮肤损伤并降低了高血清IgE水平。 CJLP133减少皮肤增厚，肥大细胞积聚到发炎部位和淋巴结肿大。在淋巴结细胞中，CJLP133抑制T细胞细胞因子（如IFN-γ，IL-4，IL-5和IL-10）的分泌。然而，CJLP133降低了淋巴结细胞中IFN-γ和IL-5与IL-10的比率，而没有降低IL-4和IL-5与IFN-γ的比率。结论是，CJLP133通过1型辅助T细胞活化和调节性T细胞活化的有序增加，在小鼠中表现出了特应性皮炎的治疗潜力。这些结果表明CJLP133可以治疗人特应性皮炎。

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