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首页> 外文期刊>Cellular immunology >Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sj?gren's syndrome
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Increased percentage of CD8+CD28- T cells correlates with clinical activity in primary Sj?gren's syndrome

机译：CD8 + CD28-T细胞百分比增加与原发性干燥综合征的临床活动相关

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摘要

The role of CD28- T cell subpopulations in primary Sj?gren's syndrome (pSS) has become controversial. Changes in the number of CD28- T cells have been demonstrated in autoimmune diseases in co-existence with Sj?gren's syndrome. The study aimed to indicate differences in the number of CD4+CD28- and CD8+CD28- T cells in patients with sicca syndrome and suspected pSS. Thirty patients with sicca syndrome at baseline were studied and followed up for 5. months. After final diagnosis, comparison was made of the previously recorded lymphocyte subpopulations in patients with pSS and those in other defined subgroups. Notably high percentages of CD8+CD28- T cells were indicated in pSS patients, which correlated with the severity of the sicca symptoms and cutaneous and muscular systemic disease activity. Changes in CD8+CD28- T cell percentages may thus assist in the early differential diagnosis of pSS patients from those with similar clinical symptoms.
机译：CD28-T细胞亚群在原发性干燥综合征（pSS）中的作用已引起争议。已经证明，在自身免疫性疾病中，CD28-T细胞数量的变化与干燥综合征共存。该研究旨在指出患有干燥综合征和疑似pSS的患者的CD4 + CD28-和CD8 + CD28-T细胞数量的差异。在基线时对30例干燥综合征患者进行了研究，并随访了5个月。最终诊断后，比较先前记录的pSS患者和其他定义亚组的淋巴细胞亚群。在pSS患者中，CD8 + CD28-T细胞的百分比显着升高，这与干燥期症状的严重程度以及皮肤和肌肉系统性疾病活动相关。因此，CD8 + CD28-T细胞百分比的变化可能有助于pSS患者与具有类似临床症状的患者的早期鉴别诊断。

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