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Identifying new small molecule anti-invasive compounds for glioma treatment

机译：鉴定用于神经胶质瘤治疗的新的小分子抗侵入化合物

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Glioblastoma is a disease with poor survival rates after diagnosis. Treatment of the disease involves debulking of the tumor, which is limited by the degree of invasiveness of the disease. Therefore, a treatment to halt the invasion of glioma is desirable for clinical implementation. There have been several candidate compounds targeting specific aspects of invasion, including cell adhesions, matrix degradation, and cytoskeletal rearrangement, but they have failed clinically for a variety of reasons. New targets against glioma invasion include upstream mediators of these classical targets in an effort to better inhibit invasion with more specificity for cancer. Included in these treatments is a new class of compounds inhibiting the generation of reactive oxygen species by targeting the NADPH oxidases. These compounds stand to inhibit multiple pathways, including nuclear factor kappa B and Akt. By conducting a screen of compounds thought to inhibit these pathways, a new compound to halt invasion was found that may have a beneficial effect against glioma, based on recent publications. Further, there are still limitations to the treatment of glioblastoma regardless of the discovery of new targets and compounds that should be addressed to better the therapies against this deadly cancer.
机译：胶质母细胞瘤是一种诊断后存活率较差的疾病。疾病的治疗涉及肿瘤的减瘤，这受疾病的侵袭程度限制。因此，对于临床实施而言，需要一种阻止神经胶质瘤侵袭的治疗方法。已经有几种针对侵袭特定方面的候选化合物，包括细胞粘附，基质降解和细胞骨架重排，但由于各种原因，它们在临床上都失败了。对抗神经胶质瘤侵袭的新靶标包括这些经典靶标的上游介体，以试图更好地抑制侵袭并对癌症具有更高的特异性。这些治疗方法包括一类新的通过靶向NADPH氧化酶抑制活性氧生成的化合物。这些化合物可以抑制多种途径，包括核因子κB和Akt。根据最近的出版物，通过筛选被认为可以抑制这些途径的化合物，发现了一种新的化合物，可以阻止入侵，这可能对胶质瘤具有有益的作用。此外，无论是否发现了新的靶标和化合物，都需要对胶质母细胞瘤进行更好的治疗，以治疗这种致命的癌症，但胶质母细胞瘤的治疗仍然存在局限性。

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