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首页> 外文期刊>Cell communication & adhesion >Cx37 and Cx43 Localize to Zona Pellucida in Mouse Ovarian Follicles
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Cx37 and Cx43 Localize to Zona Pellucida in Mouse Ovarian Follicles

机译：Cx37和Cx43定位于小鼠卵巢卵泡中的透明带。

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In the ovarian follicle, granulosa cells adjacent to the oocyte extend processes through the zona pellucida matrix, and these projections establish gap junctions both with the oocyte and with neighboring transzonal projections. The identity of connexins contributing to gap junctions between transzonal projections has not been extensively studied. Here, we examined the expression pattern of Cx37 and Cx43 in mouse zona pellucida using multiple conncxin-specific antibodies. Immunofiuorescence staining revealed abundant Cx37 and Cx43 puncta within the zona pellucida of both preantral and antral follicles. Cx37 persisted in the zona pellucida of mature follicles up to 5 h after an ovulatory stimulus whereas Cx43 was reduced in the zona pellucida by 3 h after an ovulatory stimulus. We suggest that in addition to its role in oocyte-granulosa cell communication, Cx37 could enable a distinct communication pathway between those granulosa cells that are in direct contact with the oocyte.
机译：在卵巢卵泡中，与卵母细胞相邻的颗粒细胞延伸穿过透明带状基质，并且这些突起与卵母细胞和邻近的跨区突起都建立了间隙连接。尚未深入研究促成跨区投影之间的间隙连接的连接蛋白的身份。在这里，我们使用多种连接蛋白特异性抗体检查了小鼠透明带中Cx37和Cx43的表达模式。免疫荧光染色显示窦前卵泡和肛门卵泡的透明带内有丰富的Cx37和Cx43点。在排卵刺激后5小时内，Cx37在成熟卵泡的透明带中持续存在，而在排卵刺激后3小时，Cx43在透明带中降低。我们建议，除了其在卵母细胞-颗粒细胞通信中的作用外，Cx37还可以使那些直接与卵母细胞接触的颗粒细胞之间形成独特的通信途径。

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