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首页> 外文期刊>Cell communication & adhesion >Evidence that the V832M E-Cadherin Germ-Line Missense Mutation does not Influence the Affinity of -Catenin for the Cadherin/Catenin Complex
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Evidence that the V832M E-Cadherin Germ-Line Missense Mutation does not Influence the Affinity of -Catenin for the Cadherin/Catenin Complex

机译：V832M E-钙黏着蛋白胚系错义突变不会影响-钙黏着蛋白对钙黏着蛋白/钙黏着蛋白复合物的亲和力的证据

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摘要

Mutations in E-cadherin are associated with a number of diseases, and have been shown to contribute to disease progression. In particular, 50% of hereditary diffuse gastric cancer cases have inactivating mutations in the E-cadherin gene. An interesting mutation near the beta-catenin-binding site on the cytoplasmic domain of E-cadherin (V832M) was recently reported that produces full-length protein, but exhibits decreased binding of -catenin to the cadherin/catenin complex. The study was done by transfecting mutant E-cadherin into Chinese hamster ovary fibroblast cells. Here we show that the previously reported characteristics of this mutation do not apply to human epithelial cells expressing this mutant protein and suggest that the mechanism whereby the V832M mutation in human E-cadherin promotes gastric cancer is not yet understood.
机译：E-钙粘着蛋白的突变与多种疾病有关，并已显示出与疾病进展有关。特别地，遗传性弥漫性胃癌病例中有50％的E-钙粘蛋白基因具有失活突变。最近报道了在E-钙粘蛋白（V832M）的胞质结构域上的β-catenin结合位点附近的一个有趣的突变，该突变产生全长蛋白，但表现出β-catenin与钙粘蛋白/ catenin复合物的结合减少。该研究是通过将突变的E-钙粘蛋白转染到中国仓鼠卵巢成纤维细胞中完成的。在这里，我们显示该突变的先前报道的特征不适用于表达该突变蛋白的人上皮细胞，并且表明尚不清楚人E-钙粘蛋白中V832M突变促进胃癌的机制。

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