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首页> 外文期刊>Cellular immunology >Induction of FoxP3+CD4+CD25+ regulatory T cells by a bone marrow population distinct from plasmacytoid-DC.
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Induction of FoxP3+CD4+CD25+ regulatory T cells by a bone marrow population distinct from plasmacytoid-DC.

机译：不同于浆细胞样DC的骨髓群体诱导FoxP3 + CD4 + CD25 +调节性T细胞。

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Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subsets that control regulatory T cell development have not been defined. The current study investigates the role of FC-CD3epsilon+ and FC-CD3epsilon- subpopulations in the development of FoxP3+CD4+CD25+ regulatory T cells. Here, we demonstrate that the induction of FoxP3+CD4+CD25+ regulatory T cells in coculture is mediated by not only the FC-CD3epsilon- subset but also the FC-CD3epsilon+ subset, which is distinct from plasmacytoid precursor dendritic cells (p-preDC). The identification of cell populations distinct from p-preDC that efficiently induce the generation of FoxP3+CD4+CD25+ regulatory T cells may prove useful for future therapeutic applications for the induction of tolerance following allogeneic SC transplantation.
机译：促进细胞（FC）是骨髓来源的细胞，可促进异体造血干细胞（SC）的植入并诱导移植耐受，而不会引起移植物抗宿主疾病。尽管有证据表明FC指导FoxP3 + CD4 + CD25 +调节性T细胞的发育，但尚未定义控制调节性T细胞发育的特定FC亚群。本研究调查了FC-CD3epsilon +和FC-CD3epsilon-亚群在FoxP3 + CD4 + CD25 +调节性T细胞发育中的作用。在这里，我们证明在共培养中FoxP3 + CD4 + CD25 +调节性T细胞的诱导不仅由FC-CD3epsilon-子集而且由FC-CD3epsilon +子集介导，这与浆细胞样前体树突状细胞（p-preDC）不同。有效地诱导FoxP3 + CD4 + CD25 +调节性T细胞生成的不同于p-preDC的细胞群的鉴定可能对同种异体SC移植后诱导耐受的未来治疗应用有用。

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