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首页> 外文期刊>Cell cycle >A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.
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A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

机译：Wnt-Myc驱动的肠道再生和肿瘤发生需要FAK-PI-3K-mTOR轴。

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摘要

The intestinal epithelium is a regenerative tissue that is constantly renewed by a small population of stem cells located in the intestinal crypts. Because this tissue is subject to microbial and mechanical assault, it requires significant regenerative capacity in order to maintain its structure. Defects in intestinal homeostasis can have serious consequences for human health, and unrestricted growth can result in colorectal cancer. A number of studies have implicated Src and FAK in colorectal cancer, however most of these analyses focused on the processes of invasion and metastasis, and little was known about the importance of elevated Src/FAK at the earliest stages of cancer development.1 Similarly, very little was known about the molecular pathways important for intestinal regeneration, though a role for Wnt signaling in regeneration of other systems has been suggested.
机译：肠上皮是一种再生组织，不断被位于肠隐窝中的一小部分干细胞更新。由于该组织受到微生物和机械攻击，因此需要大量的再生能力才能维持其结构。肠道稳态的缺陷可能对人类健康造成严重后果，无节制的生长会导致结直肠癌。许多研究表明Src和FAK参与了结直肠癌的治疗，但是这些分析大多集中于侵袭和转移过程，而对于癌症早期发展中Src / FAK升高的重要性知之甚少。1类似地，尽管对于Wnt信号在其他系统再生中的作用，人们对肠道再生重要的分子途径知之甚少。

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