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首页> 外文期刊>Cell communication & adhesion >The β3 Integrin Gene is Expressed at High Levels in the Major Haematopoietic and Lymphoid Organs, Vascular System, and Skeleton During Mouse Embryo Development
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The β3 Integrin Gene is Expressed at High Levels in the Major Haematopoietic and Lymphoid Organs, Vascular System, and Skeleton During Mouse Embryo Development

机译：在小鼠胚胎发育过程中，β3整合素基因在主要的造血和淋巴器官，血管系统和骨骼中高水平表达。

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摘要

Integrins are a family of cell surface molecules that mediate the attachment of cells to the extracellular matrix (ECM). These αβ heterodimers are involved in many biological processes. We used northern blotting and in situ hybridization to study the pattern of β3 integrin gene expression during mouse embryogenesis. Northern blotting detected two species of β3 mRNA from 7 to 17 days post coitum (dpc). These transcripts were abundant in the adult testis, kidney, liver, spleen, and heart. In situ hybridization experiments detected high levels of β3 in the major haematopoietic and lymphoid organs: yolk sac, liver, and thymus. Moreover, β3 transcripts were also detected in the vascular system, where β3 integrin probably plays a key role in angiogenesis and vasculogenesis. We also detected a hybridization signal in the gut, the bronchioles of the lungs, and the bladder wall. β3 transcripts were also present in the medullary regions of the adrenal glands and in the developing skeleton. Our study shows that β3 gene expression is not restricted to the liver and gut during mouse development. We also detected β3 integrin mRNA in the yolk sac, vessels, lung, bladder, and developing bones. Our data suggest that β3 integrin plays a key role in many important physiological processes like haematopoiesis, angiogenesis, phagocytosis, and bone resorption.
机译：整联蛋白是细胞表面分子家族，其介导细胞与细胞外基质（ECM）的附着。这些αβ异二聚体参与许多生物学过程。我们使用Northern印迹和原位杂交来研究小鼠胚胎发生过程中β3整合素基因表达的模式。 Northern印迹法在日光浴后7到17天检测到两种β3mRNA。这些转录本在成年睾丸，肾脏，肝脏，脾脏和心脏中丰富。原位杂交实验在主要的造血和淋巴器官：卵黄囊，肝脏和胸腺中检测到高水平的β3。此外，在血管系统中也检测到β3转录本，其中β3整联蛋白可能在血管生成和血管生成中起关键作用。我们还在肠道，肺的细支气管和膀胱壁中检测到杂交信号。 β3转录物也存在于肾上腺的髓质区域和发育中的骨骼中。我们的研究表明，在小鼠发育过程中，β3基因的表达不仅限于肝脏和肠道。我们还检测了卵黄囊，血管，肺，膀胱和发育中的骨骼中的β3整合素mRNA。我们的数据表明，β3整合素在许多重要的生理过程如造血，血管生成，吞噬作用和骨吸收中起着关键作用。

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