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首页> 外文期刊>Cell communication & adhesion >Ischemic Preconditioning Protects Against Gap Junctional Uncoupling in Cardiac Myofibroblasts
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Ischemic Preconditioning Protects Against Gap Junctional Uncoupling in Cardiac Myofibroblasts

机译：缺血预处理可防止心肌成肌纤维细胞间隙连接的解偶联

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摘要

Ischemic preconditioning increases the heart's tolerance to a subsequent longer ischemic period. The purpose of this study was to investigate the role of gap junction communication in simulated preconditioning in cultured neonatal rat cardiac myofibroblasts. Gap junctional intercellular communication was assessed by Lucifer yellow dye transfer. Preconditioning preserved intercellular coupling after prolonged ischemia. An initial reduction in coupling in response to the preconditioning stimulus was also observed. This may protect neighboring cells from damaging substances produced during subsequent regional ischemia in vivo, and may preserve gap junctional communication required for enhanced functional recovery during subsequent reperfusion.
机译：缺血预处理可增加心脏对随后更长的缺血期的耐受性。这项研究的目的是调查在培养的新生大鼠心脏成纤维细胞的模拟预处理中间隙连接通讯的作用。通过路西法黄色染料转移评估间隙连接的细胞间通讯。长时间缺血后，预处理可保留细胞间偶联。还观察到响应于预适应刺激的耦合的初始减少。这可以保护邻近的细胞免受在体内随后的局部缺血期间产生的破坏性物质的损害，并且可以保留在随后的再灌注期间增强功能恢复所需的间隙连接通讯。

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