ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin

Roman M. Salasznyk; Robert F. Klees; Mariah K. Hughlock; George E. Plopper

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ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin

机译：ERK信号通路调节人间充质干细胞在胶原蛋白I和玻连蛋白上的成骨分化

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Adhesion to the extracellular matrix (ECM) proteins collagen I and vitronectin is sufficient to drive human mesenchymal stem cells (hMSCs) into an osteogenic differentiation pathway, but the mechanisms underlying this stimulation are not well understood. We found that addition of β1 and αvβ3 integrin blocking antibodies inhibited ECM-induced ERK activation, while addition of the MEK inhibitor PD98059 blocked ERK activation, serine phosphorylation of the osteogenic transcription factor runx2/cbfa-1, osteogenic gene expression, and calcium deposition. These results suggest that ERK plays an important role in driving the ECM-induced osteogenic differentiation of hMSC.

机译：对细胞外基质（ECM）蛋白I胶原和玻连蛋白的粘附足以驱动人间充质干细胞（hMSCs）进入成骨分化途径，但是这种刺激的机制尚不十分清楚。我们发现，添加β1和αvβ3整合素阻断抗体可抑制ECM诱导的ERK活化，而添加MEK抑制剂PD98059则可以阻断ERK活化，成骨转录因子runx2 / cbfa-1的丝氨酸磷酸化，成骨基因表达和钙沉积。这些结果表明ERK在驱动ECM诱导的hMSC成骨分化中起重要作用。

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《Cell communication & adhesion》 |2004年第6期|共17页
作者
Roman M. Salasznyk; Robert F. Klees; Mariah K. Hughlock; George E. Plopper;
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正文语种 eng
中图分类细胞生物学;
关键词
Transdifferentiation; signal transduction; extracellular matrix; stem cells;

机译：转分化;信号转导;细胞外基质;干细胞;

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1. ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin [J] . Roman M. Salasznyk, Robert F. Klees, Mariah K. Hughlock, Cell communication & adhesion . 2004,第5a6期

机译：ERK信号通路调节人间充质干细胞在胶原蛋白I和玻连蛋白上的成骨分化
2. Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway [J] . YuliWang, FeiJiang, YiLiang, Stem cells international . 2016,第4期

机译：人羊膜来源的间充质干细胞通过影响ERK1 / 2信号通路促进人骨髓间充质干细胞的成骨分化。
3. Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway [J] . Wang Yuli, Jiang Fei, Liang Yi, Stem cells international . 2016,第1期

机译：通过影响ERK1 / 2信号通路，人氨基衍生的间充质干细胞促进人骨髓间充质干细胞的骨质发生分化
4. PGLA Scaffolds Coated with Collagen and Glycosaminoglycans:Impact on Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells [C] . I. Wojak, E. Pamuta, R. Hess, 23rd European conference on biomaterials 2010 . 2010

机译：PGLA胶原蛋白和糖胺聚糖涂层的支架：对人间充质干细胞的增殖和成骨分化的影响。
5. Laminin-5 promotes intracellular signaling pathways resulting in the osteogenic differentiation of human mesenchymal stem cells [D] . Klees, Robert, Francis, Jr. 2007

机译：层粘连蛋白5促进细胞内信号传导途径，导致人间充质干细胞的成骨分化
6. Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway [O] . Yuli Wang, Fei Jiang, Yi Liang, 2016

机译：人羊膜来源的间充质干细胞通过影响ERK1 / 2信号通路促进人骨髓间充质干细胞的成骨分化。
7. Focal adhesion kinase signaling pathways regulate the osteogenic differentiation of human mesenchymal stem cells [O] . Roman M. Salasznyk, Robert F. Klees, William A. Williams, 2007

机译：局灶性粘附激酶信号传导途径调节人间充质干细胞的成骨分化
8. Modeled Microgravity Disrupts Collagen I/Integrin Signaling During Osteoblastic Differentiation of Human Mesenchymal Stem Cells [R] . Meyers, Valerie E., Zayzafoon, Majd, Gonda, Steven R., 2004

机译：模拟微重力破坏人间充质干细胞成骨分化过程中的胶原蛋白I /整合素信号

ERK Signaling Pathways Regulate the Osteogenic Differentiation of Human Mesenchymal Stem Cells on Collagen I and Vitronectin

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