The importance of being modified: PCNA modification and DNA damage response

GazyI.; KupiecM.

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The importance of being modified: PCNA modification and DNA damage response

机译：修饰的重要性：PCNA修饰和DNA损伤反应

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PCNA (proliferating cell nuclear antigen) is a sliding clamp that plays important roles during DNA replication and repair. In yeast, PCNA can be modified by either mono- or poly-ubiq uitin or by addition of SUMO moieties. These different modifications direct the activity of PCNA toward alternative DNA transactions. In mammals, PCNA ubiquitination was reported, and it seems to have similar effects to those observed in yeast. However, for a long time, no SUMOylation of PCNA could be detected. Two recent papers report the detection of SUMOylated PCNA in mammalian cells. Here, we summarize similarities and differences between the various biological systems and present the current view of the way by which PCNA modification can affect DNA replication and repair pathways.

机译：PCNA（增殖细胞核抗原）是一种滑动钳，在DNA复制和修复过程中起着重要作用。在酵母中，可以通过单泛素或多泛素或通过添加SUMO部分来修饰PCNA。这些不同的修饰将PCNA的活性引向其他DNA交易。在哺乳动物中，据报道PCNA泛素化，它似乎与酵母中观察到的作用相似。然而，长期以来，无法检测到PCNA的SUMOylation。最近的两篇论文报道了在哺乳动物细胞中检测SUMO化的PCNA。在这里，我们总结了各种生物学系统之间的异同，并提出了PCNA修饰可影响DNA复制和修复途径的当前观点。

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《Cell cycle》 |2012年第14期|共4页
作者
GazyI.; KupiecM.;
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正文语种 eng
中图分类细胞生物学;
关键词
Eco1; Elg1; ESCO1; PARI; Siz1; Siz2; SRS2; SUMO; Ubc9; Ubiquitin;

机译：Eco1;Elg1;ESCO1;PARI;Siz1;Siz2;SRS2;SUMO;Ubc9;Ubiquitin;

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1. The importance of being modified: PCNA modification and DNA damage response [J] . GazyI., KupiecM. Cell cycle . 2012,第14期

机译：修饰的重要性：PCNA修饰和DNA损伤反应
2. Structurally Distinct Ubiquitin- and Sumo-Modified PCNA: Implications for Their Distinct Roles in the DNA Damage Response [J] . Tsutakawa Susan E., Yan Chunli, Xu Xiaojun, Structure . 2015,第4期

机译：结构上不同的泛素和相扑修饰的PCNA：在DNA损伤反应中不同作用的含义。
3. Interaction of Human DNA Polymerase η with Monoubiquitinated PCNA: A Possible Mechanism for the Polymerase Switch in Response to DNA Damage [J] . Patricia L. Kannouche, Jonathan Wing, Alan R. Lehmann Molecular cell . 2004,第4期

机译：人类DNA聚合酶η与单泛素化PCNA的相互作用：响应DNA损伤的聚合酶转换的可能机制
4. Identification and Characterizations of Post-translational Modifications of RNF168, a Protein Involved in DNA Damage Response [C] . Zi Wang, Yinsheng Wang ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：RNF168的翻译后修饰的鉴定和特征，DNA损伤反应中涉及的蛋白质
5. A common telomeric gene silencing assay is affected by nucleotide metabolism and the DNA damage response: Implications for the role of PCNA in heterochromatin formation. [D] . Rossmann, Marlies Petra. 2010

机译：常见的端粒基因沉默检测法会受到核苷酸代谢和DNA损伤反应的影响：PCNA在异染色质形成中的作用。
6. STRUCTURALLY DISTINCT UBIQUITIN- AND SUMO-MODIFIED PCNA: IMPLICATIONS FOR THEIR DISTINCT ROLES IN THE DNA DAMAGE RESPONSE [O] . Susan E. Tsutakawa, Chunli Yan, Xiaojun Xu, -1

机译：结构上不同的泛喹啉和相扑修饰的PCNA：它们在DNA损伤反应中的不同作用
7. Structurally Distinct Complexes of Ubiquitin and Sumo-Modified PCNA Lead to Distinct DNA Damage Response Pathways [O] . Tsutakawa Susan, Yan Chunli, Xu Xiaojun, 2014

机译：遍在蛋白和Sumo修饰的PCNA的结构上不同的复合物导致不同的DNA损伤反应途径。

The importance of being modified: PCNA modification and DNA damage response

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