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首页> 外文期刊>Cell cycle >The human papillomavirus E7 protein shines a spotlight on the pRB family member, p130.
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The human papillomavirus E7 protein shines a spotlight on the pRB family member, p130.

机译：人乳头瘤病毒E7蛋白成为pRB家族成员p130的焦点。

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The human papillomavirus life cycle.1 Human papillomaviruses (HPVs) are small DNA viruses which initially infect the basal cells of the cutaneous or mucosal epithelium. Some HPVs, referred to as low risk HPVs and exemplified by HPV 6/11, cause benign hyperproliferative lesions, such as genital warts. Other HPVs, referred to as high risk HPVs and exemplified by HPV 16/18/31, cause lower genital tract cancers (e.g., cervical cancer) and some head and neck cancers. All HPVs have two phases to their life cycles. In the non-productive phase, the viral genome is maintained as a low copy number plasmid in the proliferating compartment (the basal cell layer) of the squamous epithelium. The subsequent productive phase, in which virus is produced, takes place in the differentiated compartment of the epithelium. Since the HPV genome replicates in these differentiated cells which would have normally exited the cell cycle, HPVs must generate or maintain an environment conducive to viral DNA synthesis and the completion of the replication cycle. The HPV E7 protein is required for DNA synthesis in this suprabasal compartment.The role of pRB/E2F family members in proliferation and differentiation.The high risk E7 proteins interact with members of the retinoblastoma (pRB) family and target them for degradation. The three members, pRB, p107, and pRB2/pl30 differ in their expression during the cell cycle and differentiation. pl30 is most highly expressed in quiescent and differentiating cells; pi 07 is expressed during S phase; and pRB is expressed throughout the cell cycle. In turn, these proteins interact with the E2F family of transcription factors, with pRB primarily interacting with E2F1-3 and pl07/pl30 interacting with E2F4 and 5. The E2F family regulates genes required for G_1/S and G_2/M transitions and binding of E7 proteins to pRB family members releases activating E2F factors to induce expression of these genes. Until the paper of Zhang et al., 2006, it was thought that a key difference between the low and high risk HPV E7 proteins was that only high risk E7 proteins targeted the pRB family members for degradation. Now Zhang et al. 2006 have shown that pl30 is targeted for degradation by low risk.E7 and that pl30 targeting correlates with die delay of differentiation.
机译：人乳头瘤病毒的生命周期。1人乳头瘤病毒（HPV）是小的DNA病毒，最初会感染皮肤或粘膜上皮的基底细胞。一些HPV称为低风险HPV，以HPV 6/11为例，会引起良性过度增殖性病变，例如尖锐湿疣。其他HPV称为高风险HPV，以HPV 16/18/31为例，可导致下生殖道癌症（例如子宫颈癌）和某些头颈癌。所有HPV的生命周期都有两个阶段。在非生产期，病毒基因组在鳞状上皮的增殖区室（基底细胞层）中以低拷贝数的质粒形式存在。随后的生产阶段，其中产生病毒，发生在上皮细胞的分化区室中。由于HPV基因组在正常情况下已经退出细胞周期的这些分化细胞中复制，因此HPV必须产生或维持有利于病毒DNA合成和复制周期完成的环境。 HPV E7蛋白是该上隔区中DNA合成所必需的。pRB / E2F家族成员在增殖和分化中的作用。高风险E7蛋白与视网膜母细胞瘤（pRB）家族的成员相互作用并将其靶向降解。 pRB，p107和pRB2 / p130这三个成员在细胞周期和分化过程中的表达不同。 pl30在静止和分化细胞中表达最高; pi 07在S阶段表示; pRB在整个细胞周期中表达。反过来，这些蛋白质与E2F转录因子家族相互作用，其中pRB主要与E2F1-3相互作用，而pl07 / pl30与E2F4和5相互作用。E2F家族调节G_1 / S和G_2 / M过渡和结合蛋白的作用所需的基因。 pRB家族成员的E7蛋白释放活化的E2F因子以诱导这些基因的表达。直到Zhang等人在2006年发表论文之前，人们一直认为低风险和高风险HPV E7蛋白之间的主要区别在于，只有高风险E7蛋白才能靶向降解pRB家族成员。现在张等人。 2006年的研究表明，pl30的目标是低风险降解。E7的目标是与分化延迟相关。

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