...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Comprehensive I-125 multi-seed comparison for prostate brachytherapy: Dosimetry and visibility analysis.
【24h】

Comprehensive I-125 multi-seed comparison for prostate brachytherapy: Dosimetry and visibility analysis.

机译：前列腺近距离放射治疗的I-125多种子综合比较：剂量和可见性分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To compare the visibility of different manufacturers I-125, seeds, and to investigate the effect of differences in dosimetry on treatment planning. MATERIALS AND METHODS: Oncura Oncoseed, Oncura Echoseed, IBT Intersource, Bebig Isoseed and Nucletron Selectseed were investigated. The point dose at increasing distances from each seed type was calculated for three different angles; theta=0 degrees , 45 degrees and 90 degrees (where theta=0 degrees lies parallel to seed length). 10 patient plans were used to assess the effect of a change in dosimetry on treatment planning and quality of prostate and rectum implant indices such as Vp100, Vp200, Dp90, Vr100 and Vr69. All implant indices and dosimetry data were compared to Oncoseed. Visibility under X-ray, fluoroscopy, CT and MRI was investigated using prostate phantoms created in-house. Statistical significance was calculated using paired two-tailed t-tests. RESULTS: Dosimetric analysis was carried out for seeds of the same source strength. Differences in dose increase closer to the centre of each source, with the largest changes occurring for the angle theta=0 degrees . Selectseed and Isoseed seed types provide a consistently lower dose in all three directions. Changes to Vp100 are small and statistically insignificant for all seeds except Selectseed which shows a statistically significant decrease of 0.04% (p=0.02). Changes to Vp150 and Vp200 are statistically significant (p<0.01), with Intersource showing the greatest increase in both values. Selectseed shows a decrease in both Vp150 and Vp200. Echoseed shows an increase in both Vp150 and Vp200. Changes to D90 are statistically significant (p<0.01), with Intersource showing the greatest increase, followed by Isoseed then Echoseed. Selectseed shows a decrease in D90. For Vr100 there is no statistically significant change for any seed type. However, all seeds except Selectseed show a statistically significant increase in the value of Vr69, with Intersource showing the greatest increase. On fluoroscopy and X-ray images, Intersource seeds appear least visible, Echoseed and Oncoseed are similar, and Isoseed and Selectseed are most visible. Ultrasound greyscale beam profiles show that all seed images have a FWHM larger than the Oncoseed image. The CT greyscale beam profiles are similar for all seed images. The MRI signal voids are similar for all seed images except Intersource which shows a larger signal void. CONCLUSIONS: The greatest changes to point dose occur at very close distances to the seeds. Changing seed type may require a treatment replan to maintain satisfactory DVH criteria. Visibility on US and CT is similar, though it may vary on MRI, X-ray and fluoroscopy.
机译：目的：比较不同制造商I-125，种子的可见性，并研究剂量学差异对治疗计划的影响。材料与方法：研究了Oncura Oncoseed，Oncura Echoseed，IBT Intersource，Bebig Isoseed和Nucletron Selectseed。对于三种不同的角度，计算距每种种子类型增加距离的点剂量。 theta = 0度，45度和90度（其中theta = 0度平行于种子长度）。使用10个患者计划来评估剂量学变化对治疗计划以及前列腺和直肠植入物指数（例如Vp100，Vp200，Dp90，Vr100和Vr69）的质量的影响。将所有植入物指数和剂量学数据与Oncoseed进行比较。使用内部创建的前列腺体模研究了X射线，荧光透视，CT和MRI下的可见性。使用配对的双尾t检验计算统计学显着性。结果：对相同强度的种子进行了剂量分析。剂量差异在靠近每个源的中心处增加，最大变化发生在角度theta = 0度处。精选种子和等剂量种子类型在所有三个方向上始终提供较低的剂量。 Vp100的变化很小，并且对于除Selectseed种子以外的所有种子，在统计上均不显着，Selectseedse的种子显示统计学上的显着下降0.04％（p = 0.02）。 Vp150和Vp200的变化具有统计学意义（p <0.01），Intersource显示这两个值的增加幅度最大。精选种子显示Vp150和Vp200均下降。 Echoseed显示Vp150和Vp200均增加。 D90的变化具有统计学意义（p <0.01），其中Intersource显示最大的增加，其次是Isoseed然后是Echoseed。精选种子显示D90降低。对于Vr100，任何种子类型都没有统计学上的显着变化。但是，除Selectseed种子外，所有种子的Vr69值均显示出统计学上的显着增加，其中Intersource的增加最大。在荧光检查和X射线图像上，源间种子看起来最不可见，内切和内切种子相似，而内切和精选种子最明显。超声灰度光束轮廓显示，所有种子图像的FWHM均大于Oncoseed图像。所有种子图像的CT灰度光束轮廓均相似。对于所有种子图像，MRI信号空隙均类似，但Intersource显示较大的信号空隙。结论：最大剂量变化发生在离种子很近的位置。改变种子类型可能需要重新计划治疗，以保持令人满意的DVH标准。尽管在MRI，X射线和荧光检查中可能有所不同，但US和CT上的可见性相似。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号