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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Brachytherapy with transperineal (125)Iodine seeds for localized prostate cancer.
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Brachytherapy with transperineal (125)Iodine seeds for localized prostate cancer.

机译：经会阴（125）碘种子进行近距离放射治疗可治疗局部前列腺癌。

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BACKGROUND AND PURPOSE: To analyze the treatment results of transperineal (125)Iodine seeds in localized prostate cancer. PATIENTS AND METHODS: Between 1985 and 1996, 102 patients with T1-T2 N0 prostate cancer were treated with transperineal (125)Iodine seed implants at the Academic Medical Centre in Amsterdam. Tumours were classified as T1c in four patients, T2a in 73 patients and T2b in 25 patients. The mean pre-treatment PSA was 17 ng/ml. The (125)Iodine seeds were implanted transperineally under transrectal ultrasound guidance. The mean prostate volume was 31 ml (range 15-48 ml). An average of 49 seeds (range 29-74) was implanted. The dose to the periphery of the prostate was 160 Gy. Until 1988, 27 patients had additional external pelvic irradiation to a dose of 40 Gy in 20 daily fractions of 2 Gy. RESULTS: The 5- and 7-year actuarial survival rates were 77 and 63%, respectively (median 102 months). Ten patients (9.5%) died from prostate cancer. The 5- and 7-year clinical progression rates were 12 and 17%, respectively. Biochemical failure rates at 5 and 7 years were 39 and 44%, respectively. Age, alkaline phosphatase, creatinine, differentiation grade, additional treatment, staging procedure, number of seeds, prostate volume, treatment period and PSA were analyzed as prognostic factors. Only pre-treatment PSA was a prognosticator of clinical and biochemical outcome but not of survival. Biochemical control at 6 years varied from 30% for pre-treatment PSA values higher than 20 ng/ml to 95% for values < or =8 ng/ml. Forty-one out of 49 patients who were sexually active before brachytherapy maintained sexual function during the follow-up. Complete urinary incontinence occurred in one patient. No rectal complications were seen in patients receiving brachytherapy alone. CONCLUSIONS: Transperineal (125)Iodine seeds brachytherapy in localized prostate cancer achieves a good clinical control and overall survival with acceptable late toxicity. Biochemical failure was strongly correlated to the pre-treatment PSA value.
机译：背景与目的：分析经会阴（125）碘种子在局限性前列腺癌中的治疗效果。患者与方法：1985年至1996年，在阿姆斯特丹的学术医学中心对102例T1-T2 N0前列腺癌患者进行了经会阴（125）碘种子植入治疗。肿瘤被分类为4例患者中的T1c，73例患者中的T2a和25例患者中的T2b。平均治疗前PSA为17 ng / ml。在经直肠超声引导下经会阴植入（125）碘种子。平均前列腺体积为31 ml（范围为15-48 ml）。平均植入49颗种子（范围29-74）。前列腺周围的剂量为160 Gy。直到1988年，有27位患者接受了额外的骨盆外照射，剂量为40 Gy，每天20 Gy的剂量为20 Gy。结果：5年和7年的精算生存率分别为77％和63％（中位102个月）。十名患者（9.5％）死于前列腺癌。 5年和7年的临床进展率分别为12％和17％。 5年和7年生化失败率分别为39％和44％。将年龄，碱性磷酸酶，肌酐，分化程度，补充治疗，分期程序，种子数，前列腺体积，治疗时间和PSA作为预后因素进行分析。只有治疗前PSA可以预示临床和生化结果，但不能预示生存。 6年时的生化控制范围从治疗前PSA值高于20 ng / ml的30％到值<或= 8 ng / ml的95％不等。在近距离放疗前发生性活跃的49位患者中，有41位在随访期间保持了性功能。一名患者完全尿失禁。仅接受近距离放射治疗的患者未见直肠并发症。结论：局部会阴前列腺癌的经会阴（125）碘种子近距离放射治疗可实现良好的临床控制和总体生存，并具有可接受的后期毒性。生化衰竭与治疗前PSA值密切相关。

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