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Cellular radiosensitivity of patients with papillary thyroid cancer.

机译:甲状腺乳头状癌患者的细胞放射敏感性。

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摘要

Cultured skin fibroblasts from patients with papillary (differentiated) thyroid carcinomas were compared to those from healthy subjects, ataxia telangiectasia (AT) homozygotes and AT heterozygotes for colony-forming ability after low dose-rate irradiation, and post-irradiation DNA synthesis as indicated by uptake of [3H]-thymidine. The cells from the cancer patients exhibited enhanced radiosensitivity (intermediate between normal and AT) and less than normal level of radioinduced inhibition of DNA synthesis.
机译:将低剂量率辐照后和放射后DNA合成后,将来自乳头状(分化)甲状腺癌患者的培养皮肤成纤维细胞与健康受试者,共济失调毛细血管扩张(AT)纯合子和AT杂合子的皮肤成纤维细胞形成菌落的能力进行比较吸收[3H]-胸苷。来自癌症患者的细胞表现出增强的放射敏感性(介于正常和AT之间),且低于放射诱导的DNA合成抑制水平。

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