...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship.
【24h】

Dysphagia disorders in patients with cancer of the oropharynx are significantly affected by the radiation therapy dose to the superior and middle constrictor muscle: A dose-effect relationship.

机译：口咽癌患者的吞咽困难会受到上，中段收缩肌放射治疗剂量的显着影响：剂量效应关系。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE/OBJECTIVE: To assess the relationship between the radiation therapy (RT) dose received by the muscular components of the swallowing (sw) apparatus and - dysphagia related - quality of life (QoL) in oropharyngeal cancer. MATERIALS/METHODS: Between 2000 and 2005, 81 patients with SCC of the oropharynx were treated by 3DCRT or IMRT, with or without concomitant chemotherapy (CHT); 43 out of these 81 patients were boosted by brachytherapy (BT). Charts of 81 patients were reviewed with regard to late dysphagia complaints; 23% experienced severe dysphagia. Seventeen patients expired. Fifty-six out of 64 (88%) responded to quality of life (QoL) questionnaires; that is, the Performance Status Scales of List, EORTC H&N35, and the M.D. Anderson Dysphagia Inventory. The superior (scm), middle (mcm), and inferior constrictor muscle (icm), the cricopharyngeus muscle and the inlet of the esophagus, are considered of paramount importance for swallowing. The mean dose was calculated in the muscular structures. Univariate analysis and multivariate analysis were performed using the proportional odds model. RESULTS: Mean follow-up was 18 months (range 2-34) for IMRT, and 46 months for 3DCRT (range 2-72). At 3-years, a LRC of 84%, DFS of 78% and OS of 77% were observed. A significant correlation was observed between the mean dose in the scm and mcm, and severe dysphagia complaints (univariate analysis). A steep dose-effect relationship, with an increase of the probability of dysphagia of 19% with every additional 10Gy, was established. In the multivariate analysis, BT (dose) was the only significant factor. CONCLUSION: A dose-effect relationship between dose and swallowing complaints was observed. One way to improve the QoL is to constrain the dose to be received by the swallowing muscles.
机译：目的/目的：评估吞咽（sw）装置的肌肉部件所接受的放射治疗（RT）剂量与口咽癌患者吞咽困难相关的生活质量（QoL）之间的关系。材料/方法：在2000年至2005年之间，对81例口咽SCC患者进行了3DCRT或IMRT联合或不联合化疗（CHT）。这81例患者中有43例通过近距离放射疗法（BT）加强治疗。回顾了81例晚期吞咽困难患者的病历。 23％的人出现严重吞咽困难。十七名患者死亡。 64个问卷中有56个（88％）回答了生活质量（QoL）问卷;即清单的绩效状态量表，EORTC H＆N35和M.D. Anderson吞咽困难量表。上咽（scm），中部（mcm）和下strict缩肌（icm），咽咽肌和食道入口被认为对吞咽至关重要。计算肌肉结构的平均剂量。使用比例赔率模型进行单变量和多变量分析。结果：IMRT平均随访18个月（范围2-34），3DCRT平均随访46个月（范围2-72）。在3年时，观察到LRC为84％，DFS为78％和OS为77％。 scm和mcm的平均剂量与严重吞咽困难主诉之间存在显着相关性（单因素分析）。建立了陡峭的剂量效应关系，吞咽困难每增加10Gy，吞咽困难的可能性就会增加19％。在多变量分析中，BT（剂量）是唯一重要因素。结论：观察到剂量与吞咽不适之间存在剂量-效应关系。改善QoL的一种方法是限制吞咽肌肉要接受的剂量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号