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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma.
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Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma.

机译：基于加速器的硼中子捕获疗法（AB-BNCT）对多发性肝肿瘤和恶性胸膜间皮瘤治疗的影响。

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BACKGROUND AND PURPOSE: To confirm the feasibility of accelerator-based BNCT (AB-BNCT) for treatment of multiple liver tumors and malignant pleural mesothelioma (MPM), we compared dose distribution and irradiation time between AB-BNCT and reactor-based BNCT (RB-BNCT). MATERIAL AND METHODS: We constructed treatment plans for AB-BNCT and RB-BNCT of four multiple liver tumors and six MPM. The neutron beam data on RB-BNCT were those from the research reactor at Kyoto University Research Reactor Institute (KURRI). The irradiation time and dose-volume histogram data were assessed for each BNCT system. RESULTS: In BNCT for multiple liver tumors, when the 5 Gy-Eq dose was delivered as the mean dose to the healthy liver tissues, the mean dose delivered to the liver tumors by AB-BNCT and RB-BNCT was 68.1 and 65.1 Gy-Eq, respectively. In BNCT for MPM, when the mean lung dose to the normal ipsilateral lung was 5 Gy-Eq, the mean dose delivered to the MPM tumor by AB-BNCT and RB-BNCT was 20.2 and 19.9 Gy-Eq, respectively. Dose distribution analysis revealed that AB-BNCT is superior to RB-BNCT for treatment of deep-seated tumors. CONCLUSIONS: The feasibility of the AB-BNCT system constructed at our institute was confirmed from a clinical viewpoint in BNCT for multiple liver tumors and MPM.
机译：背景与目的：为证实基于促进剂的BNCT（AB-BNCT）治疗多发性肝肿瘤和恶性胸膜间皮瘤（MPM）的可行性，我们比较了AB-BNCT与基于反应器的BNCT（RB -BNCT）。材料与方法：我们为四个多发性肝肿瘤和六个MPM的AB-BNCT和RB-BNCT制定了治疗计划。 RB-BNCT上的中子束数据来自京都大学研究堆研究所（KURRI）的研究堆。评估每个BNCT系统的照射时间和剂量-体积直方图数据。结果：在多发性肝肿瘤的BNCT中，当将5 Gy-Eq剂量作为平均剂量递送至健康肝组织时，AB-BNCT和RB-BNCT递送至肝肿瘤的平均剂量分别为68.1和65.1 Gy-分别在用于MPM的BNCT中，当正常同侧肺的平均肺部剂量为5 Gy-Eq时，AB-BNCT和RB-BNCT递送至MPM肿瘤的平均剂量分别为20.2和19.9 Gy-Eq。剂量分布分析显示，AB-BNCT在治疗深部肿瘤方面优于RB-BNCT。结论：从临床角度出发，我院构建的AB-BNCT系统在多发性肝肿瘤和MPM的临床研究中得到了证实。

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