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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.
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Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer.

机译：XRCC1和RAD51基因中的单核苷酸多态性与头颈癌临床放射敏感性之间的关联。

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PURPOSE: Individual variability in radiosensitivity is large in cancer patients. Single nucleotide polymorphisms (SNPs) in genes involved in DNA repair and in protection against reactive oxygen species (ROS) could be responsible for such cases of radiosensitivity. We investigated the association between the occurrence of acute reactions in 101 patients with squamous cell carcinoma of the head and neck (SCCHN) after radiotherapy (RT) and five genetic polymorphisms: XRCC1 c.1196A>G, XRCC3 c.722C>T, RAD51 (c.-3429G>C, c.-3392G>T), and GSTP1 c.313A>G. MATERIALS AND METHODS: Genetic polymorphisms were detected by high resolution melting analysis (HRMA). The development of acute reactions (oral mucositis, skin erythema and dysphagia) associated with genetic polymorphisms was modeled using Cox proportional hazards, accounting for biologically effective dose (BED). RESULTS: Development of grade >/=2 mucositis was increased in all patients (chemo-radiotherapy and radiotherapy alone) with XRCC1-399Gln allele (HR=1.72). The likelihood of developing grade >/=2 dysphagia was higher in carriers of RAD51 c.-3429 CC/GC genotypes (HR=4.00). The presence of at least one SNP or the co-presence of both SNPs in XRCC1 p.Gln399Arg /RAD51 c.-3429 G>C status were associated to higher likelihood of occurrence of acute toxicities (HR=2.03). CONCLUSIONS: Our findings showed an association between genetic polymorphisms, XRCC1 c.1196A>G and RAD51 c.-3429 G>C, and the development of radiation-induced toxicities in SCCHN patients.
机译：目的：癌症患者的放射敏感性个体差异很大。涉及DNA修复和抗活性氧（ROS）保护的基因中的单核苷酸多态性（SNP）可能是这种放射敏感性的原因。我们研究了101例头颈鳞状细胞癌（SCCHN）放疗（RT）后的急性反应发生与五种基因多态性之间的关系：XRCC1 c.1196A> G，XRCC3 c.722C> T，RAD51 （c.-3429G> C，c.-3392G> T）和GSTP1 c.313A> G。材料与方法：通过高分辨率熔解分析（HRMA）检测到遗传多态性。与遗传多态性相关的急性反应（口腔粘膜炎，皮肤红斑和吞咽困难）的发生采用考克斯比例风险建模，并考虑了生物有效剂量（BED）。结果：XRCC1-399Gln等位基因（HR = 1.72）的所有患者（单独进行化学放疗和放疗）的粘膜炎分级均> / = 2。在RAD51 c.-3429 CC / GC基因型携带者中，发展为> / = 2吞咽困难的可能性更高（HR = 4.00）。 XRCC1 p.Gln399Arg / RAD51 c.-3429 G> C状态中至少存在一个SNP或两个SNP并存与发生急性毒性的可能性更高（HR = 2.03）。结论：我们的研究结果表明，遗传多态性，XRCC1 c.1196A> G和RAD51 c.-3429 G> C与SCCHN患者放射致毒性的发展之间存在关联。

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