...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Adjuvant chemoradiotherapy with or without intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma
【24h】

Adjuvant chemoradiotherapy with or without intraoperative radiotherapy for the treatment of resectable locally advanced gastric adenocarcinoma

机译：伴或不伴术中放疗的辅助放化疗治疗可切除的局部晚期胃腺癌

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: To document the long-term efficacy of intraoperative electron radiotherapy (IOERT) followed by concurrent chemotherapy and external-beam radiotherapy (EBRT) in the management of locally advanced gastric cancer. Materials and methods: A total of 97 consecutive patients with T3/4 or N+ gastric adenocarcinoma were enrolled. Fifty-one patients received adjuvant chemoradiotherapy (EBRT group) and 46 received IOERT (dose range, 12-15 Gy) followed by chemoradiotherapy (EBRT + IOERT group). Results: The 5-year locoregional control rates were 50% and 35% in the two groups with or without IOERT, respectively (p = 0.04). Two patients had recurrence within the IOERT field in the EBRT + IOERT group and 14 patients recurred in the same area in the EBRT group (p = 0.02). Multivariate analyses revealed that adjuvant IOERT was an independent prognosticator for both local-regional control (p = 0.02) and disease-free survival (p = 0.05). G3/4 late toxicity was observed in 5 patients in the EBRT + IOERT group, but none in the EBRT group (p = 0.02). Conclusions: Higher radiation dose may contribute to the improvement of local control, especially in the field encompassed by IOERT. The addition of IOERT to surgery and adjuvant chemoradiation deserves further investigation in a randomized trial.
机译：目的：记录术中电子放疗（IOERT），同时进行的化学疗法和体外束放疗（EBRT）在治疗局部晚期胃癌中的长期疗效。材料和方法：总共纳入97例连续的T3 / 4或N +胃腺癌患者。 51例患者接受了辅助放化疗（EBRT组），46例接受了IOERT（剂量范围12-15 Gy），随后接受了放化疗（EBRT + IOERT组）。结果：有或没有IOERT的两组的5年局部区域控制率分别为50％和35％（p = 0.04）。 EBRT + IOERT组中有2例在IOERT区域内复发，EBRT组中有14例在同一区域复发（p = 0.02）。多因素分析显示，IOERT辅助剂对于局部区域控制（p = 0.02）和无病生存期（p = 0.05）都是独立的预后指标。在EBRT + IOERT组中有5名患者观察到G3 / 4晚期毒性，但在EBRT组中没有观察到（3/4）（p = 0.02）。结论：较高的辐射剂量可能有助于改善局部控制，特别是在IOERT所涉领域。在手术和辅助放化疗中添加IOERT值得在随机试验中进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号