Fasting levels of hepatic p-S6 are increased in old mice

LeontievaO.V.; PaszkiewiczG.M.; BlagosklonnyM.V.

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Fasting levels of hepatic p-S6 are increased in old mice

机译：老年小鼠的肝p-S6的空腹水平增加

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TOR is involved in aging in a wide range of species from yeast to mammals. Here we show that, after overnight fasting, mTOR activity is higher in the livers of 28 months old female mice compared with middle-aged mice. Taken together with previous reports, our data predict that the life-extending effect of calorie restriction (CR) may be diminished,if CR is started in very old age. In contrast, rapamycin is known to be effective, even when started late in life.

机译：TOR参与了从酵母到哺乳动物的多种物种的衰老。在这里，我们显示，禁食过夜后，与中年小鼠相比，在28个月大的雌性小鼠的肝脏中mTOR活性更高。结合以前的报告，我们的数据预测，如果CR在很老的年龄开始，那么卡路里限制（CR）的延寿作用可能会减弱。相反，已知雷帕霉素即使在生命后期开始也有效。

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《Cell cycle》 |2014年第17期|共4页
作者
LeontievaO.V.; PaszkiewiczG.M.; BlagosklonnyM.V.;
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正文语种 eng
中图分类细胞生物学;
关键词
Aging; MTOR; Rapalogs; Rapamycin; Senescence;

机译：衰老;MTOR;雷帕霉素;雷帕霉素;衰老;

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1. Fasting levels of hepatic p-S6 are increased in old mice [J] . LeontievaO.V., PaszkiewiczG.M., BlagosklonnyM.V. Cell cycle . 2014,第17期

机译：老年小鼠的肝p-S6的空腹水平增加
2. Aqueous extract of Ocimum canum decreases levels of fasting blood glucose and free radicals and increases antiatherogenic lipid levels in mice. [J] . Nyarko AK, Asare Anane H, Ofosuhene M, Vascular pharmacology . 2002,第6期

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5. HeLa cell lines producing infectious replication-defective HIV virions with varyinggp160 densities indicate that increasing cellulargp160 levels cause an increase in cell-to-cell fusion, while increasing viralgp160 levels exert a biphasic effect on infectivity. [D] . Berg, Werner Mente. 1999

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6. Fasting levels of hepatic p-S6 are increased in old mice [O] . Olga V Leontieva, Geraldine M Paszkiewicz, Mikhail V Blagosklonny 2014

机译：老年小鼠的肝p-S6空腹水平增加
7. Increased Hepatic Forkhead Box M1B (FoxM1B) Levels in Old-aged Mice Stimulated Liver Regeneration through Diminished p27Kip1 Protein Levels and Increased Cdc25B Expression [O] . Xinhe Wang, Katherine Krupczak-Hollis, Yongjun Tan, 2002

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8. Effect of T-2 Toxin, Fasting, and 2-Methyl-thiazolidine-4-carboxylate, a Glutathione Prodrug, on Hepatic Glutathione Levels 1,2 [R] . Fricke, R. F., Jorge, J. M. 1986

机译：T-2毒素，空腹和谷胱甘肽前药2-甲基 - 噻唑烷-4-羧酸盐对肝脏谷胱甘肽水平的影响1,2

Fasting levels of hepatic p-S6 are increased in old mice

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