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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model.
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Noninvasive monitoring of radiation-induced treatment response using proton magnetic resonance spectroscopy and diffusion-weighted magnetic resonance imaging in a colorectal tumor model.

机译：在结直肠肿瘤模型中使用质子磁共振波谱和弥散加权磁共振成像对辐射诱导的治疗反应进行无创监测。

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BACKGROUND AND PURPOSE: To examine whether in vivo proton magnetic resonance spectroscopy ((1)H MRS) and diffusion-weighted magnetic resonance imaging (DW-MRI) can monitor radiation-induced changes in HT29 xenografts in mice. MATERIALS AND METHODS: HT29 xenografts in mice received a dose of 15Gy. In vivo(1)H MRS and DW-MRI were acquired pretreatment and 1, 3, 6 and 10 days post-irradiation. After imaging, tumors were excised for histological analysis. The amounts of necrosis, fibrosis and viable cells in the cross sections were scored and compared to changes in apparent diffusion coefficient (ADC) and choline/water ratio. RESULTS: Radiation-induced necrosis in the xenografts was observed as increased tumor ADC. In-growth of fibrosis three days post-irradiation restricting water mobility was accompanied by decreased tumor ADC. Choline/water ratio correlated with metabolic activity and tumor growth. CONCLUSIONS: ADC and choline/water ratio assessed by in vivo DW-MRI and (1)H MRS depicts radiation-inducedchanges in HT29 xenografts following irradiation.
机译：背景与目的：检查体内质子磁共振波谱（（1）H MRS）和扩散加权磁共振成像（DW-MRI）是否可以监测小鼠体内HT29异种移植物的辐射诱导变化。材料与方法：小鼠HT29异种移植物的剂量为15Gy。在照射前，照射后1、3、6和10天获得了vivo（1）H MRS和DW-MRI。成像后，切除肿瘤以进行组织学分析。对横截面中的坏死，纤维化和活细胞的数量进行评分，并将其与表观扩散系数（ADC）和胆碱/水比的变化进行比较。结果：随着肿瘤ADC的增加，观察到放射诱导的异种坏死。辐照后三天纤维化的增长限制了水的流动性，并伴有肿瘤ADC的降低。胆碱/水比与代谢活性和肿瘤生长相关。结论：通过体内DW-MRI和（1）H MRS评估的ADC和胆碱/水比描述了辐射后HT29异种移植物的辐射诱导变化。

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