...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Postoperative high-dose pelvic radiotherapy for N+ prostate cancer: Toxicity and matched case comparison with postoperative prostate bed-only radiotherapy
【24h】

Postoperative high-dose pelvic radiotherapy for N+ prostate cancer: Toxicity and matched case comparison with postoperative prostate bed-only radiotherapy

机译：术后大剂量骨盆放疗对N +前列腺癌的毒性和术后仅前列腺卧床放疗的匹配病例比较

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose To report on toxicity of postoperative high-dose whole-pelvis radiotherapy (WPRT) with androgen deprivation therapy for lymph node metastasized (N1) prostate cancer (PC). To perform a matched-case analysis to compare this toxicity profile to postoperative prostate bed-only radiotherapy (PBRT). Materials and methods Forty-eight N1-PC patients were referred for WPRT and 239 node-negative patients for PBRT. Patients were matched 1:1 according to pre-treatment demographics, symptoms, treatment and tumor characteristics. Mean dose to the prostate bed was 75 Gy (WPRT-PBRT) and 54 Gy to the elective nodes (WPRT) in 36 or 37 fractions. End points are genito-urinary (GU) and gastro-intestinal (GI) toxicity. Results After WPRT, 35% developed grade 2 (G2) and 4% G3 acute GU toxicity. Acute GI toxicity developed in 42% (G2). Late GU toxicity developed in 36% (G2) and 7% (G3). One patient had G4 incontinence. Recuperation occurred in 59%. Late GI toxicity developed in 25% (G2) with 100% recuperation. Incidence of acute and late GI toxicity was higher following WPRT compared to PBRT (p ≤ 0.041). GU toxicity was similar. With WPRT mean dose to bladder and rectosigmoid were higher. Conclusions Postoperative high-dose WPRT comes at the cost of a temporary increase in G2. GI toxicity compared to PBRT because larger volumes of rectosigmoid are irradiated.
机译：目的报告术后大剂量全骨盆放疗（WPRT）与雄激素剥夺治疗对淋巴结转移（N1）前列腺癌（PC）的毒性。为了进行匹配病例分析，以比较该毒性谱图与术后仅前列腺床放疗（PBRT）。材料和方法WPRT转诊了48例N1-PC患者，PBRT转诊了239个淋巴结阴性患者。根据治疗前的人口统计学，症状，治疗和肿瘤特征，将患者按1：1比例匹配。前列腺床的平均剂量为75 Gy（WPRT-PBRT），而对选择性结节（WPRT）的平均剂量为36 Gy或37 Gy。终点是生殖泌尿（GU）和胃肠道（GI）毒性。结果WPRT后，35％的患者产生2级（G2）和4％的G3急性GU毒性。急性胃肠道毒性的发生率为42％（G2）。 GU的晚期毒性发展为36％（G2）和7％（G3）。一名患者患有G4尿失禁。修复率达到59％。晚期胃肠道毒性以25％（G2）和100％的治愈率发展。 WPRT后的急性和晚期胃肠道毒性的发生率高于PBRT（p≤0.041）。 GU的毒性相似。使用WPRT时，膀胱和直肠乙状结肠的平均剂量较高。结论术后大剂量WPRT以暂时增加G2为代价。与PBRT相比，胃肠道毒性更大，因为照射了更大的直肠乙状结肠。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号