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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity.
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Normal cellular radiosensitivity in an adult Fanconi anaemia patient with marked clinical radiosensitivity.

机译：具有显着临床放射敏感性的成年Fanconi贫血患者的正常细胞放射敏感性。

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摘要

BACKGROUND: Fanconi anaemia is a rare disease associated with cellular sensitivity to chemicals (e.g. mitomycin C and diepoxybutane); variable but mild cellular radiosensitivity has also been reported. MATERIALS AND METHODS: A 32-year-old patient with Fanconi anaemia and tonsillar carcinoma, treated by radiotherapy, was found to exhibit profound clinical radiosensitivity. Confluent, ulcerating oropharyngeal mucositis developed after a conventionally fractionated dose of 34Gy and healing was incomplete by 2 months after cessation of therapy. RESULTS: Cellular radiosensitivity assays and RPLD studies from this patient did not suggest any major detectable radiosensitivity. CONCLUSION: There is a discrepancy between the observed clinical radiosensitivity and the usual "predictive" radiosensitivity assays in this patient with Fanconi anaemia.
机译：背景：范可尼贫血是一种罕见的疾病，与细胞对化学物质（例如丝裂霉素C和二环氧丁烷）敏感有关;可变但轻度的细胞放射敏感性也已有报道。材料和方法：发现一名32岁的范科尼贫血和扁桃体癌患者接受放射治疗后，表现出深远的临床放射敏感性。常规分次剂量34Gy后出现融合性溃疡性口咽粘膜炎，治疗停止后2个月愈合不完全。结果：该患者的细胞放射敏感性测定和RPLD研究未发现任何可检测的主要放射敏感性。结论：在该范可尼贫血患者中观察到的临床放射敏感性与通常的“预测性”放射敏感性测定之间存在差异。

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