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New partners for Chk1.

机译：Chk1的新合作伙伴。

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摘要

Important discoveries that come as a complete surprise and cause radical intellectual reorientations in a field of investigation are not rare in modern biomedical research. In some ways, they actually represent a form of reward to those active in that field. The field of cellular responses to DNA damage (DDR) has had a fair share of such surprising discoveries. Thus, the Ku protein was considered an autoantigen with transcription factor properties before its actual function in the repair of DNA double strand breaks (DSBs) by non homologous end joining (NHEJ) was elucidated. The DNA dependent protein kinase catalytic subunit (DNA-PKcs) was an exotic protein kinase with unknown functions, showing a puzzling DNA requirement for activity, before its involvement in NHEJ and its interactions with Ku were characterized. And DNA Ligase IV was a biochemically unknown entity before the gene was cloned and its function in NHEJ elucidated.
机译：在现代生物医学研究中，重要的发现令人惊讶，并引起研究领域的根本性知识重新定位。在某些方面，它们实际上是对那些活跃于该领域的人的一种奖励。细胞对DNA损伤（DDR）的反应领域中有许多令人惊讶的发现。因此，在阐明其通过非同源末端连接（NHEJ）修复DNA双链断裂（DSB）的实际功能之前，Ku蛋白被认为是具有转录因子特性的自身抗原。 DNA依赖性蛋白激酶催化亚基（DNA-PKcs）是一种功能未知的奇异蛋白激酶，显示出令人困惑的DNA活性要求，然后才对其参与NHEJ及其与Ku的相互作用进行了表征。 DNA Ligase IV在克隆该基因并阐明其在NHEJ中的功能之前是一个生化未知的实体。

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