• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >The role of FAN1 nuclease in the Fanconi anemia pathway.
【24h】

The role of FAN1 nuclease in the Fanconi anemia pathway.

机译：FAN1核酸酶在Fanconi贫血途径中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

While the primary function of ribosomal proteins (RPs) has been seen as facilitating the folding of rRNA and ensuring the speed and accuracy of protein synthesis, extra-ribosomal functions of RPs have also been documented over the years.1 Recently, the ability of RPs to modulate the p53-Mdm2 axis in response to perturbations in ribosomal biogenesis by different stimuli, including DNA damage, was elucidated. An increasing number of RPs, namely L5, LI 1, L23, L26, S3 and S7, were shown to stabilize and activate p53 through their interaction with Mdm2, an E3 ubiquitin ligase that functions as a negative regulator of p53.2 The p53-Mdrr2 axis, a key modulator of the cellular response to stressors such as DNA damage, oncogene activation and hypoxia is frequently mutated in cancer.3 The interplay between RPs and the p53-Mdm2 axis suggests that modulation of Mdm2 function by Mdm2-interacting RPs is a common mechanism employed by cells in response to multiple stress stimuli.
机译：尽管核糖体蛋白（RPs）的主要功能被认为促进了rRNA的折叠并确保了蛋白质合成的速度和准确性，但这些年来RPs的核糖体外功能也得到了证明。1最近，RPs的能力阐明了调节p53-Mdm2轴以响应不同刺激（包括DNA损伤）引起的核糖体生物发生中的扰动。越来越多的RP（即L5，L1，L23，L26，S3和S7）通过与Mdm2（一种E3泛素连接酶，可作为p53.2的负调控子）相互作用来稳定和激活p53。 Mdrr 2轴是细胞对应激物如DNA损伤，致癌基因激活和缺氧等应激反应的关键调节因子，在癌症中经常发生突变。3RP与p53-Mdm2轴之间的相互作用表明，Mdm2相互作用可调节Mdm2功能。 RPs是细胞响应多种应激刺激的常见机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号