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首页> 外文期刊>Cell cycle >Feeding the hungry enemy: an endothelial recipe for glioma stem cells.
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Feeding the hungry enemy: an endothelial recipe for glioma stem cells.

机译：喂养饥饿的敌人：神经胶质瘤干细胞的内皮配方。

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摘要

Glioblastoma multiforme are malignant primary tumors of the central nervous system that remain one of the most deadly cancers in adults. One recent concept proposes that cancer cells derive from a small fraction of self-sustaining cells with the exclusive ability to initiate and propagate the tumor. In brain tumors, glioblastoma stem-like cells (GSCs) might participate in resistance to radiotherapies and contribute to recurrence and aggressiveness. Conversely, reducing the GSC reservoir slows tumor progression in animal models.Cancer stem cells, including GSCs, are believed to lodge in a defined micro-environment. Indeed, almost 20 years since the term "stem cell niche" was coined, a large body of work has supported its importance in the regulation of stem cell renewal and fate. Notably, this niche feeds the malignant stem-like subpopulation through locally secreted factors and metabolites. Similarly to embryonic and adult stem cells, cancer stem cells segregate within a specific and confined niche that contains a vascular structure. In the case of glioblastoma, GSCs have been identified surrounded by endothelial cells. Moreover, GSCs have been reported to differentiate toward the endothelial lineage and compose tumor vasculature.
机译：多形胶质母细胞瘤是中枢神经系统的恶性原发肿瘤，仍然是成人中最致命的癌症之一。最近的一个概念提出，癌细胞源自一小部分具有自我维持能力的细胞，这些细胞具有引发和繁殖肿瘤的独特能力。在脑肿瘤中，胶质母细胞瘤干样细胞（GSC）可能参与对放射疗法的抗性并有助于复发和侵袭性。相反，减少GSC贮藏库可减缓动物模型中的肿瘤进展，包括GSC在内的癌症干细胞被认为存在于确定的微环境中。的确，自“干细胞小生境”一词诞生以来已有近20年的时间，大量工作支持了其在调节干细胞更新和命运方面的重要性。值得注意的是，这种小生境通过局部分泌的因子和代谢产物滋养了恶性茎状亚群。类似于胚胎干细胞和成体干细胞，癌症干细胞在包含血管结构的特定且狭窄的小生境中分离。在胶质母细胞瘤的情况下，已鉴定出被内皮细胞包围的GSC。此外，据报道，GSC可向内皮谱系分化并组成肿瘤脉管系统。

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