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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Assessment of set-up variability during deep inspiration breath hold radiotherapy for breast cancer patients by 3D-surface imaging
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Assessment of set-up variability during deep inspiration breath hold radiotherapy for breast cancer patients by 3D-surface imaging

机译：通过3D表面成像评估乳腺癌患者深吸气屏息放疗期间的装置变异性

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Purpose: To quantify set-up uncertainties during voluntary deep inspiration breath hold (DIBH) radiotherapy using 3D-surface imaging in patients with left sided breast cancer. Material and methods: Nineteen patients were included. Cone-beam CT-scan (CBCT) was used for online set-up correction while patients were instructed to perform a voluntary DIBH. The reproducibility of the DIBH during treatment was monitored with 2D-fluoroscopy and portal imaging. Simultaneously, a surface imaging system was used to capture 3D-surfaces throughout CBCT acquisition and delivery of treatment beams. Retrospectively, all captured surfaces were registered to the planning-CT surface. Interfraction, intra-fraction and intra-beam set-up variability were quantified in left-right, cranio-caudal and anterior-posterior direction. Results: Inter-fraction systematic (Σ) and random (σ) translational errors (1SD) before and after set-up correction were between 0.20-0.50 cm and 0.09-0.22 cm, respectively, whereas rotational Σ and σ errors were between 0.08 and 1.56°. The intra-fraction Σ and σ errors were ≤0.14 cm and ≤0.47°. The intra-beam SD variability was ≤0.08 cm and ≤0.28° in all directions. Conclusion: Quantification of 3D set-up variability in DIBH RT showed that patients are able to perform a very stable and reproducible DIBH within a treatment fraction. However, relatively large inter-fraction variability requires online image guided set-up corrections.
机译：目的：为了量化使用左侧乳癌患者使用3D表面成像的自愿性深吸气屏息（DIBH）放疗期间的设置不确定性。材料和方法：纳入19例患者。锥束CT扫描（CBCT）用于在线设置校正，同时指示患者进行自愿DIBH。 DIBH在治疗过程中的重现性通过2D荧光透视和门静脉成像进行监测。同时，在整个CBCT采集和输送治疗束过程中，使用了表面成像系统来捕获3D表面。回顾性地，所有捕获的曲面都已注册到Planning-CT曲面。在左右，颅尾和前后方向上量化了分数，分数内和波束内的变异性。结果：校正前和校正后的系统间分数（Σ）和随机（σ）平移误差（1SD）分别在0.20-0.50 cm和0.09-0.22 cm之间，而旋转Σ和σ误差在0.08-0.2之间。 1.56°。分数内的Σ和σ误差分别为≤0.14cm和≤0.47°。光束内SD的所有方向的变异性均≤0.08cm和≤0.28°。结论：定量DIBH RT中3D设置的变异性表明，患者能够在治疗分数内执行非常稳定且可重现的DIBH。但是，较大的分数间差异需要在线图像引导的设置校正。

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