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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Volume and dosimetric changes and initial clinical experience of a two-step adaptive intensity modulated radiation therapy (IMRT) scheme for head and neck cancer
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Volume and dosimetric changes and initial clinical experience of a two-step adaptive intensity modulated radiation therapy (IMRT) scheme for head and neck cancer

机译：头颈癌两步式自适应强度调制放射治疗（IMRT）方案的体积和剂量变化以及初步临床经验

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Purpose: The aim of this study was to show the benefit of a two-step intensity modulated radiotherapy (IMRT) method by examining geometric and dosimetric changes. Material and Methods: Twenty patients with pharyngeal cancers treated with two-step IMRT combined with chemotherapy were included. Treatment-planning CT was done twice before IMRT (CT-1) and at the third or fourth week of IMRT for boost IMRT (CT-2). Transferred plans recalculated initial plan on CT-2 were compared with the initial plans on CT-1. Dose parameters were calculated for a total dose of 70 Gy for each plan. Results: The volumes of primary tumors and parotid glands on CT-2 regressed significantly. Parotid glands shifted medially an average of 4.2 mm on CT-2. The mean doses of the parotid glands in the initial and transferred plans were 25.2 Gy and 30.5 Gy, respectively. D2 (dose to 2% of the volume) doses of the spinal cord were 37.1 Gy and 39.2 Gy per 70 Gy, respectively. Of 15 patients in whom xerostomia scores could be evaluated 1-2 years after IMRT, no patient complained of grade 2 or more xerostomia. Conclusions: This two-step IMRT method as an adaptive RT scheme could adapt to changes in body contour, target volumes and risk organs during IMRT. ? 2013 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology.
机译：目的：本研究的目的是通过检查几何和剂量学变化来展示两步强度调制放射疗法（IMRT）方法的益处。材料与方法：纳入20例经两步IMRT联合化学疗法治疗的咽癌患者。在IMRT之前（CT-1）和IMRT的第3或第4周进行两次治疗计划CT以加强IMRT（CT-2）。将重新计算的CT-2初始计划的转移计划与CT-1的初始计划进行了比较。计算每个计划的总剂量为70 Gy的剂量参数。结果：CT-2上的原发肿瘤和腮腺的体积明显消退。腮腺在CT-2上平均向内移动4.2毫米。初始和转移计划中腮腺的平均剂量分别为25.2 Gy和30.5 Gy。脊髓的D2剂量（占体积的2％）分别为每70 Gy 37.1 Gy和39.2 Gy。在IMRT后1-2年可以评估口干评分的15例患者中，没有患者抱怨2级以上口干。结论：这种两步式IMRT方法作为自适应RT方案，可以适应IMRT期间身体轮廓，目标体积和危险器官的变化。 ？ 2013 Elsevier Ireland Ltd.保留所有权利。放射疗法和肿瘤学。

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